NDLI: Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung.

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Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kastenmuller, Wolfgang Germain, Ronald N. Vrisekoop, Nienke Gerner, Michael Y. Egen, Jackson G. Torabi-Parizi, Parizad
Description	Author Affiliation: Torabi-Parizi P ( Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.)
Abstract	Exposure to pathogens in the periphery elicits effector T cell differentiation in local lymph nodes followed by migration of activated T cells to and within the infected site. However, the relationships among pathogen abundance, Ag display on MHC molecules, effector T cell dynamics, and functional responses at the infected sites are incompletely characterized. In this study, we compared CD4(+) T cell effector dynamics and responses during pulmonary mycobacterial infection versus acute influenza infection. Two-photon imaging together with in situ as well as ex vivo analysis of cytokine production revealed that the proportion of migration-arrested, cytokine-producing effector T cells was dramatically higher in the influenza-infected lungs due to substantial differences in Ag abundance in the two infectious states. Despite the marked inflammatory conditions associated with influenza infection, histocytometric analysis showed that cytokine production was focal, with a restriction to areas of significant Ag burden. Optimal effector function is thus constrained by the availability of TCR ligands, pointing to the value of increasing Ag stimulation rather than effector numbers in harnessing CD4(+) T cells for therapeutic purposes in such conditions.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1301743
Journal	The Journal of Immunology
Issue Number	4
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Cytokines Metabolism Orthomyxoviridae Infections Receptors, Antigen, T-cell Tuberculosis, Pulmonary Adoptive Transfer Animals Antigen Presentation Transplantation Cell Differentiation Cell Movement Biosynthesis Inflammation Interferon-gamma Liver Lung Lymph Nodes Lymphocyte Activation Mice Mice, Inbred C57bl Mycobacterium Bovis Mycobacterium Tuberculosis Orthomyxoviridae Tumor Necrosis Factor-alpha Research Support, N.i.h., Intramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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