NDLI: Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.

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Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.

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Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nijagal, Amar Lescano, Ninnia Wegorzewska, Marta Wong, Charissa M. Tang, Qizhi Le, Tom MacKenzie, Tippi C.
Description	Author Affiliation: Wegorzewska M ( Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143.)
Abstract	Fetal interventions to diagnose and treat congenital anomalies are growing in popularity but often lead to preterm labor. The possible contribution of the maternal adaptive immune system to postsurgical pregnancy complications has not been explored. We recently showed that fetal intervention in mice increases maternal T cell trafficking into the fetus and hypothesized that this process also may lead to increased maternal T cell recognition of the foreign conceptus and subsequent breakdown in maternal-fetal tolerance. In this study, we show that fetal intervention in mice results in accumulation of maternal T cells in the uterus and that these activated cells can produce effector cytokines. In adoptive transfer experiments, maternal T cells specific for a fetal alloantigen proliferate after fetal intervention, escape apoptosis, and become enriched compared with endogenous T cells in the uterus and uterine-draining lymph nodes. Finally, we demonstrate that such activation and accumulation can have a functional consequence: in utero transplantation of hematopoietic cells carrying the fetal alloantigen leads to enhanced demise of semiallogeneic fetuses within a litter. We further show that maternal T cells are necessary for this phenomenon. These results suggest that fetal intervention enhances maternal T cell recognition of the fetus and that T cell activation may be a culprit in postsurgical pregnancy complications. Our results have clinical implications for understanding and preventing complications associated with fetal surgery such as preterm labor.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1302403
Journal	The Journal of Immunology
Issue Number	4
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fetal Therapies Histocompatibility, Maternal-fetal Immunology Pregnancy Complications T-lymphocytes, Regulatory Transplantation Adoptive Transfer Animals Antigens, Cd4 Metabolism Cytokines Fetus Immune Tolerance Interleukin-2 Receptor Alpha Subunit Lymphocyte Activation Maternal-fetal Exchange Mice Mice, Inbred Balb C Mice, Inbred C3h Mice, Inbred C57bl Pregnancy T-lymphocyte Subsets Uterus Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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