NDLI: KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2014 Volume: 192 Issue: 12

Year: 2014 Volume: 192 Issue: 11

Year: 2014 Volume: 192 Issue: 10

Year: 2014 Volume: 192 Issue: 9

Year: 2014 Volume: 192 Issue: 8

Year: 2014 Volume: 192 Issue: 7

Year: 2014 Volume: 192 Issue: 6

Year: 2014 Volume: 192 Issue: 5

Year: 2014 Volume: 192 Issue: 4

Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.

Mutagenesis of Ly49B reveals key structural elements required for promiscuous binding to MHC class I molecules and new insights into the molecular evolution of Ly49s.

Hydrogen sulfide increases survival during sepsis: Protective effect of CHOP inhibition

IDO-independent suppression of T cell effector function by IFN-Î³-licensed human mesenchymal stromal cells.

The aryl hydrocarbon receptor promotes IL-10 production by NK cells.

Autoimmune vitiligo does not require the ongoing priming of naive CD8 T cells for disease progression or associated protection against melanoma.

KLRG1+ NK cells protect T-bet-deficient mice from pulmonary metastatic colorectal carcinoma.

Noncore RAG1 regions promote Vß rearrangements and ß T cell development by overcoming inherent inefficiency of Vß recombination signal sequences.

Enforced expression of Gata3 in T cells and group 2 innate lymphoid cells increases susceptibility to allergic airway inflammation in mice.

Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.

Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.

Transcriptional regulator CTR9 inhibits Th17 differentiation via repression of IL-17 expression.

Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions.

Second-generation Langerhans cells originating from epidermal precursors are essential for CD8+ T cell priming.

Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia.

Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-ß-induced Foxp3 expression.

Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling.

Pathogen-related differences in the abundance of presented antigen are reflected in CD4+ T cell dynamic behavior and effector function in the lung.

Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

Gr1+ cells suppress T-dependent antibody responses in (NZB x NZW)F1 male mice through inhibition of T follicular helper cells and germinal center formation.

Induction of endotoxin tolerance by pathogenic Neisseria is correlated with the inflammatory potential of lipooligosaccharides and regulated by microRNA-146a.

CD19 and CD32b differentially regulate human B cell responsiveness.

A genetic defect in mice that impairs missing self recognition despite evidence for normal maturation and MHC class I-dependent education of NK cells.

Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-/- umbilical cord blood.

Casein kinase 1Î³1 inhibits the RIG-I/TLR signaling pathway through phosphorylating p65 and promoting its degradation.

NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis.

Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy.

CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis.

Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway.

Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.

Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia.

PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2.

Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis.

Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.

Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.

Role of Th1/Th17 balance regulated by T-bet in a mouse model of Mycobacterium avium complex disease.

Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor.

IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells.

Islet antigen-specific Th17 cells can induce TNF- -dependent autoimmune diabetes.

IL-17A promotes the exacerbation of IL-33-induced airway hyperresponsiveness by enhancing neutrophilic inflammation via CXCR2 signaling in mice.

CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals.

TNF- -dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma.

Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes.

IL-37 ameliorates the inflammatory process in psoriasis by suppressing proinflammatory cytokine production.

Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.

Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells.

FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo.

KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys.

Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization.

Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance.

CD4+ T cell responses to the Plasmodium falciparum erythrocyte membrane protein 1 in children with mild malaria.

B cell depletion curtails CD4+ T cell memory and reduces protection against disseminating virus infection.

Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses.

Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease.

A spliced antigenic peptide comprising a single spliced amino acid is produced in the proteasome by reverse splicing of a longer peptide fragment followed by trimming.

MMTV superantigens coerce an unconventional topology between the TCR and MHC class II.

FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.

PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.

Infection and cellular defense dynamics in a novel 17ß-estradiol murine model of chronic human group B streptococcus genital tract colonization reveal a role for hemolysin in persistence and neutrophil accumulation.

Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism.

Computational approach to characterize causative factors and molecular indicators of chronic wound inflammation.

Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodies.

Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps.

-Galactosylceramide but not phenyl-glycolipids induced NKT cell anergy and IL-33-mediated myeloid-derived suppressor cell accumulation via upregulation of egr2/3.

HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.

Endogenous retroviruses and the development of cancer.

Year: 2014 Volume: 192 Issue: 3

Year: 2014 Volume: 192 Issue: 2

Year: 2014 Volume: 192 Issue: 1

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dudley, Dawn M. Neidermyer, William J. Connole, Michelle O'Connor, David H. Colantonio, Arnaud D. Schafer, Jamie L. Evans, David T.
Description	Author Affiliation: Schafer JL ( Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115)
Abstract	The identification of MHC class I ligands for rhesus macaque killer cell Ig-like receptors (KIRs) is fundamental to our basic understanding of KIR and MHC class I coevolution and to the study of NK cell responses in this nonhuman primate model for AIDS and other viral diseases. In this study, we show that Mamu-KIR3DL01, which is expressed by â ¼90% of rhesus macaques, recognizes MHC class I molecules with a Bw4 motif. Primary NK cells expressing Mamu-KIR3DL01 were identified by staining with a mAb which, in this study, was shown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233. The cytolytic activity of Mamu-KIR3DL01(+) NK cells was suppressed by cell lines expressing the Bw4 molecules Mamu-B007:01, -B041:01, -B058:02, and -B065:01. The Bw4 motif was necessary for Mamu-KIR3DL01 recognition because substitutions in this region abrogated Mamu-KIR3DL01(+) NK cell inhibition. However, the presence of a Bw4 motif was not sufficient for recognition because another Bw4 molecule, Mamu-B017:01, failed to suppress the cytolytic activity of these NK cells. Replacement of three residues in Mamu-B017:01, predicted to be KIR contacts based on the three-dimensional structure of the human KIR3DL1-HLA-Bw4 complex, with the corresponding residues at these positions for the other Mamu-Bw4 ligands restored Mamu-KIR3DL01(+) NK cell inhibition. These results define the ligand specificity of one of the most polymorphic and commonly expressed KIRs in the rhesus macaque and reveal similarities in Bw4 recognition by Mamu-KIR3DL01 and human KIR3DL1, despite the absence of an orthologous relationship between these two KIRs or conservation of surface residues predicted to interact with MHC class I ligands.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1302883
Journal	The Journal of Immunology
Issue Number	4
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hla-b Antigens Immunology Histocompatibility Antigens Class I Metabolism Killer Cells, Natural Macaca Mulatta Receptors, Kir Amino Acid Sequence Animals Cell Line Epitopes, T-lymphocyte Jurkat Cells Ligands Genetics Molecular Sequence Data Protein Binding Protein Structure, Tertiary Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in