NDLI: M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.

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M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.

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M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yoshida, Shigeo Zhou, Yedi Kobayashi, Yoshiyuki Yoshimura, Takeru Kubo, Yuki Nakama, Takahito Ishibashi, Tatsuro Nakao, Shintaro Ishikawa, Keijiro Akashi, Koichi Oshima, Yuji Miyawaki, Kohta Yamaguchi, Muneo
Description	Country affiliation: Japan Author Affiliation: Zhou Y ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Yoshida S ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Nakao S ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Yoshimura T ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Kobayashi Y ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Nakama T ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Kubo Y ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Miyawaki K ( Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Yamaguchi M ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Ishikawa K ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Oshima Y ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Akashi K ( Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.); Ishibashi T ( Department of Ophthalmology Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.)
Abstract	PURPOSE: To investigate the roles played by M2 macrophages in a mouse model of oxygen-induced retinopathy (OIR). METHODS: Oxygen-induced retinopathy was induced in C57BL/6J mice by exposing postnatal day seven (P7) pups to 75% oxygen and then returning them to room air at P12. Real-time RT-PCR and immunofluorescence staining were used to assess the levels and distributions of different macrophage markers. Bone marrow-derived M1 and M2 macrophages and mannosylated clodronate liposomes (MCLs) were injected into the vitreous on P12 to examine the effects at P17. M2 macrophages were cocultured with human retinal endothelial cells (HRECs) to examine their effects on proliferation and tube formation. RESULTS: The results showed that the M2 macrophages, rather than M1 phenotype, were highly expressed in OIR mice. The number of M2 macrophages had increased significantly at P17, and the increase was closely associated with the presence of neovascular tufts in the OIR retinas. Selective depletion of M2 macrophages suppressed the pathological neovascularization and promoted physiological revascularization. In contrast, intravitreal injection of bone marrow-derived M2 macrophages or the culture supernatants promoted pathological neovascularization and inhibited physiological revascularization. In an in vitro coculture system, M2-polarized macrophages significantly promoted proliferation and tube formation of HRECs. CONCLUSIONS: These results indicated that M2 macrophages, rather than M1, play an important role in promoting retinal pathological neovascularization probably by producing secreted factors. Thus, targeting M2 macrophages could be a potential therapeutic option for inhibiting retinal pathological neovascularization.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Macrophages Metabolism Retinal Neovascularization Pathology Retinopathy Of Prematurity Animals Animals, Newborn Cells, Cultured Coculture Techniques Disease Models, Animal Fluorescein Angiography Infant, Newborn Mice Mice, Inbred C57bl Oxygen Toxicity Genetics Etiology Chemically Induced Complications Reverse Transcriptase Polymerase Chain Reaction Vascular Endothelial Growth Factor A Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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