NDLI: In Vivo and In Vitro Feasibility Studies of Intraocular Use of Polyethylene Glycol-Based Synthetic Sealant to Close Retinal Breaks in Porcine and Rabbit Eyes.

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In Vivo and In Vitro Feasibility Studies of Intraocular Use of Polyethylene Glycol-Based Synthetic Sealant to Close Retinal Breaks in Porcine and Rabbit Eyes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hoshi, Sujin Kaji, Yuichi Arai, Mikki Hirose, Tatsuo Sugiura, Yoshimi Oshika, Tetsuro Okamoto, Fumiki
Description	Country affiliation: Japan Author Affiliation: Hoshi S ( Department of Ophthalmology Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.); Okamoto F ( Department of Ophthalmology Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.); Arai M ( Arai Eye Clinic, Fukuoka, Japan 3The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States.); Hirose T ( The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States 4Boston Eye Group, Brookline, Massachusetts, United States.); Sugiura Y ( Department of Ophthalmology Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.); Kaji Y ( Department of Ophthalmology Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.); Oshika T ( Department of Ophthalmology Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.)
Abstract	PURPOSE: Absorbable polyethylene glycol-based synthetic sealant (PEG sealant) polymerizes under xenon illumination and forms a clear, flexible, and firmly adherent hydrogel. The intraocular biocompatibility of PEG sealant and efficacy for closing retinal breaks were evaluated. METHODS: In an in vitro study, retinal detachment with a tear was created in porcine eyecups after vitreous gel removal. Polyethylene glycol-based synthetic sealant was applied to cover the tear and polymerized with a 40-second application of xenon light. Retinal adhesion strength was tested by forcefully squirting balanced salt solution (BSS) onto the retinal tear. Polyethylene glycol-based synthetic sealant was soaked in the BSS, incubated at 37°C, and the pH measured periodically over 72 hours. In an in vivo study, PEG sealant was injected into the vitreous cavity of the left eyes of rabbits. Ophthalmologic examinations were performed and bilateral ERGs were recorded simultaneously before and 28 days after injection. The eyes were enucleated for histological evaluation. RESULTS: Adhesion of PEG sealant to the retina was good in BSS. A forceful squirt of BSS onto the retinal tear covered with PEG sealant did not detach the retina; the retinal tear without PEG sealant detached immediately. The pH of the BSS containing PEG sealant was between 7.2 and 8.2. No inflammatory reaction was observed in the eyes throughout 28 days of follow-up. The ERGs recorded before and after injection showed typical patterns. Histological examinations did not reveal any abnormality or inflammation. CONCLUSIONS: Polyethylene glycol-based synthetic sealant appeared to effectively seal retinal breaks and was not toxic to the eye.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Polyethylene Glycols Administration & Dosage Retinal Perforations Therapy Tissue Adhesives Animals Disease Models, Animal Electroretinography Feasibility Studies In Vitro Techniques Intravitreal Injections Rabbits Diagnosis Physiopathology Swine Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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