NDLI: In Vivo Retinal Vascular Oxygen Tension Imaging and Fluorescein Angiography in the Mouse Model of Oxygen-Induced Retinopathy

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2013 Volume: 54 Issue: 14

Year: 2013 Volume: 54 Issue: 13

Year: 2013 Volume: 54 Issue: 12

Year: 2013 Volume: 54 Issue: 11

Year: 2013 Volume: 54 Issue: 10

Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling.

Inhibitory effect of microRNA-34a on retinal pigment epithelial cell proliferation and migration.

Laser capture microdissection-directed profiling of glycolytic and mTOR pathways in areas of selectively ablated Müller cells in the murine retina.

ABCA4 gene screening by next-generation sequencing in a British cohort.

Complement factor C3a alters proteasome function in human RPE cells and in an animal model of age-related RPE degeneration.

Patient-related and system-related barriers to glaucoma follow-up in a county hospital population.

Vitreous levels of active ocriplasmin following intravitreal injection: results of an ascending exposure trial.

Horizontal saccade dynamics after childhood monocular enucleation.

Dietary -lipoic acid prevents UVB-induced corneal and conjunctival degeneration through multiple effects.

Bleb analysis by using anterior segment optical coherence tomography in two different methods of trabeculectomy.

BDNF treatment and extended recovery from optic nerve trauma in the cat.

Effects of TGF-ß2 on cadherins and ß-catenin in human trabecular meshwork cells.

Myopia control using toric orthokeratology (TO-SEE study).

Identification of VEGF-independent cytokines in proliferative diabetic retinopathy vitreous.

CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis.

Computational model for oxygen transport and consumption in human vitreous.

Early detection of central visual function decline in cone-rod dystrophy by the use of macular focal cone electroretinogram.

Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells.

Short-term saccadic adaptation in patients with anisometropic amblyopia.

Myopia and glaucoma in the South Korean population.

UV-B-induced DNA damage and repair in the mouse lens.

Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium.

TGF-ß3 stimulates stromal matrix assembly by human corneal keratocyte-like cells.

Identification of vascular endothelial side population cells in the choroidal vessels and their potential role in age-related macular degeneration.

Laser scanning tomography in the EPIC-Norfolk Eye Study: principal components and associations.

Pigment epithelium-derived factor decreases outflow facility.

Two-photon imaging of the cornea visualized in the living mouse using vital dyes.

Difference in the properties of retinal nerve fiber layer defect between superior and inferior visual field loss in glaucoma.

Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment.

Robust and censored modeling and prediction of progression in glaucomatous visual fields.

Delta-opioid receptors attenuate TNF- -induced MMP-2 secretion from human ONH astrocytes.

Cellular fibronectin expression in human trabecular meshwork and induction by transforming growth factor-ß2.

Functional Analysis of Serially Expanded Human iPS Cell-Derived RPE Cultures

The regional extent of suppression: strabismics versus nonstrabismics.

Structural, morphological, and functional correlates of corneal endothelial toxicity following corneal exposure to sulfur mustard vapor.

The age-regulating protein klotho is vital to sustain retinal function.

The dynamic response of intraocular pressure and ocular pulse amplitude to acute hemodynamic changes in normal and glaucomatous eyes.

GABAergic control of arteriolar diameter in the rat retina.

Functional Analysis of HSF4 Mutations Found in Patients With Autosomal Recessive Congenital Cataracts

Gene expression signatures in tree shrew sclera in response to three myopiagenic conditions.

Quantitative analysis of retinal layer optical intensities on three-dimensional optical coherence tomography.

Reproducibility of SD-OCT-based ganglion cell-layer thickness in glaucoma using two different segmentation algorithms.

Effects of semaphorin 3A on retinal pigment epithelial cell activity.

IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds.

Phagocytosis of photoreceptor outer segments by transplanted human neural stem cells as a neuroprotective mechanism in retinal degeneration.

Imaging errors in localization of COMS-type plaques in choroidal melanoma brachytherapy.

Axial length as a factor associated with visual outcome after vitrectomy for diabetic macular edema.

The role of the NFAT signaling pathway in retinal neovascularization.

In Vivo Retinal Vascular Oxygen Tension Imaging and Fluorescein Angiography in the Mouse Model of Oxygen-Induced Retinopathy

Episcleral venous pressure and IOP responses to central electrical stimulation in the rat.

High resolution OCT quantitative analysis of the space between the IOL and the posterior capsule during the early cataract postoperative period.

Ocular anterior segment biometry and high-order wavefront aberrations during accommodation.

Imaging microscopic pigment chemistry in conjunctival melanocytic lesions using pump-probe laser microscopy.

Suppression of IL-22-producing T helper 22 cells by RPE cells via PD-L1/PD-1 interactions.

Prevalence and risk factors for diabetic retinopathy: the Korea National Health and Nutrition Examination Survey 2008-2011.

MicroRNA signature in wound healing following excimer laser ablation: role of miR-133b on TGFß1, CTGF, SMA, and COL1A1 expression levels in rabbit corneal fibroblasts.

Choroidal volume variations during childhood.

Retinal function and neural conduction along the visual pathways in affected and unaffected carriers with Leber's hereditary optic neuropathy.

Morphologic characteristics and proliferation of rabbit corneal stromal cells onto complexes of collagen-chitosan-sodium hyaluronate under simulated microgravity.

Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy.

The effects of blur and eccentric viewing on adult acuity for pediatric tests: implications for amblyopia detection.

Distinct characteristics of inferonasal fundus autofluorescence patterns in stargardt disease and retinitis pigmentosa.

Reticular pseudodrusen in early age-related macular degeneration are associated with choroidal thinning.

Apoptotic photoreceptor loss and altered expression of lysosomal proteins in the nclf mouse model of neuronal ceroid lipofuscinosis.

Migration of retinal pigment epithelium cells is regulated by protein kinase C in vitro.

Ultrastructural Localization of GPR179 and the Impact of Mutant Forms on Retinal Function in CSNB1 Patients and a Mouse Model

Standardized baseline human corneal subbasal nerve density for clinical investigations with laser-scanning in vivo confocal microscopy.

Functional characterization and multimodal imaging of treatment-naive 'quiescent' choroidal neovascularization.

Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls.

Endogenous IgG affects the cell biology of RPE cells and involves the TLR4 pathway.

Serum ferritin and hemoglobin are independently associated with wider retinal venular caliber: the Tromsø Study 2001-2008.

Macular choroidal thickness and volume in healthy pediatric individuals measured by swept-source optical coherence tomography.

A new human primary epithelial cell culture model to study conjunctival inflammation.

Aurintricarboxylic acid inhibits complement activation, membrane attack complex, and choroidal neovascularization in a model of macular degeneration.

Involvement of Nox2 NADPH oxidase in retinal neovascularization.

Retinal segmentation as noninvasive technique to demonstrate hyperplasia in ataxia of Charlevoix-Saguenay.

Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.

Stimulation of pontine reticular formation in monkeys with strabismus.

Retinal arterial and venous oxygen saturation is altered in diabetic patients.

Changes for the future.

Exploiting mTOR signaling: a novel translatable treatment strategy for traumatic optic neuropathy?

Year: 2013 Volume: 54 Issue: 9

Year: 2013 Volume: 54 Issue: 8

Year: 2013 Volume: 54 Issue: 7

Year: 2013 Volume: 54 Issue: 6

Year: 2013 Volume: 54 Issue: 5

Year: 2013 Volume: 54 Issue: 4

Year: 2013 Volume: 54 Issue: 3

Year: 2013 Volume: 54 Issue: 2

Year: 2013 Volume: 54 Issue: 1

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

In Vivo Retinal Vascular Oxygen Tension Imaging and Fluorescein Angiography in the Mouse Model of Oxygen-Induced Retinopathy

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reddy, Sekhar P. Raj, J. Usha Teng, Pang-yu Blair, Norman P. Wanek, Justin Chau, Felix Y. Shahidi, Mahnaz Reddy, Narsa M. Mezu-Ndubuisi, Olachi J.
Description	Author Affiliation: Mezu-Ndubuisi OJ ( Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.)
Abstract	PURPOSE: Oxygenation abnormalities are implicated in the development of retinopathy of prematurity (ROP). The purpose of this study is to report in vivo retinal vascular oxygen tension (PO2) measurements and fluorescein angiography (FA) findings in the mouse model of oxygen-induced retinopathy (OIR). METHODS: We exposed 19 neonatal mice to 77% oxygen from postnatal day 7 (P7) to P12 (OIR), while 11 neonatal mice were kept under room air (control). Using phosphorescence lifetime imaging, retinal vascular PO2 was measured followed by FA. Repeated measures ANOVA was performed to determine the effects of blood vessel type (artery and vein) and group (OIR and control) on PO2. Avascular retinal areas were measured from FA images in OIR mice. RESULTS: There was a significant effect of vessel type on PO2 (P < 0.001). The effect of group on PO2 was not significant (P = 0.3), indicating similar PO2 between OIR and control mice. The interaction between group and vessel type was significant (P = 0.03), indicating a larger arteriovenous PO2 difference in OIR mice than control mice. In control mice, FA displayed normal vascularization, while FA of OIR mice showed abnormalities, including dilation and tortuosity of major retinal blood vessels, and avascular regions. In OIR mice, the mean percent avascular retinal area was 33% ± 18%. CONCLUSIONS: In vivo assessment of retinal vascular oxygen tension and vascularization patterns demonstrated abnormalities in the mouse model of OIR. This approach has the potential to improve understanding of retinal vascular development and oxygenation alterations due to ROP and other ischemic retinal diseases.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.13-12126
Journal	Investigative Opthalmology & Visual Science
Issue Number	10
Volume Number	54
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2013-10-23
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Oxygen Metabolism Retinal Vessels Retinopathy Of Prematurity Analysis Of Variance Animals Disease Models, Animal Fluorescein Angiography Mice Mice, Inbred C57bl Pharmacology Pathology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in