NDLI: The Effect of PKC on the Light Response of Rod Bipolar Cells in the Mouse Retina.

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The Effect of PKC on the Light Response of Rod Bipolar Cells in the Mouse Retina.

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The Effect of PKC on the Light Response of Rod Bipolar Cells in the Mouse Retina.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xiong, Wei-Hong Morgans, Catherine W. Pennesi, Mark E. Duvoisin, Robert M. Pang, Ji-Jie Wu, Samuel M.
Description	Country affiliation: United States Author Affiliation: Xiong WH ( Department of Physiology & Pharmacology Oregon Health & Science University, Portland, Oregon, United States.); Pang JJ ( Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, United States.); Pennesi ME ( Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.); Duvoisin RM ( Department of Physiology & Pharmacology Oregon Health & Science University, Portland, Oregon, United States.); Wu SM ( Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, United States.); Morgans CW ( Department of Physiology & Pharmacology Oregon Health & Science University, Portland, Oregon, United States.)
Abstract	PURPOSE: Protein kinase C (PKC ) is abundantly expressed in rod bipolar cells (RBCs) in the retina, yet the physiological function of PKC in these cells is not well understood. To elucidate the role of PKC in visual processing in the eye, we examined the effect of genetic deletion of PKC on the ERG and on RBC light responses in the mouse. METHODS: Immunofluorescent labeling was performed on wild-type (WT), TRPM1 knockout, and PKC knockout (PKC-KO) retina. Scotopic and photopic ERGs were recorded from WT and PKC-KO mice. Light responses of RBCs were measured using whole-cell recordings in retinal slices from WT and PKC-KO mice. RESULTS: Protein kinase C alpha expression in RBCs is correlated with the activity state of the cell. Rod bipolar cells dendrites are a major site of PKC phosphorylation. Electroretinogram recordings indicated that loss of PKC affects the scotopic b-wave, including a larger peak amplitude, longer implicit time, and broader width of the b-wave. There were no differences in the ERG a- or c-wave between PKC KO and WT mice, indicating no measurable effect of PKC in photoreceptors or the RPE. The photopic ERG was unaffected consistent with the lack of detectable PKC in cone bipolar cells. Whole-cell recordings from RBCs in PKC-KO retinal slices revealed that, compared with WT, RBC light responses in the PKC-KO retina are delayed and of longer duration. CONCLUSIONS: Protein kinase C alpha plays an important modulatory role in RBCs, regulating both the peak amplitude and temporal properties of the RBC light response in the rod visual pathway.
ISSN	01460404
e-ISSN	15525783
DOI	10.1167/iovs.15-16622
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genetics Gene Expression Regulation Protein Kinase C-alpha Retinal Bipolar Cells Enzymology Retinal Diseases Retinal Rod Photoreceptor Cells Visual Pathways Animals Blotting, Western Disease Models, Animal Electroretinography Genetic Therapy Immunohistochemistry Mice Mice, Knockout Patch-clamp Techniques Biosynthesis Pathology Physiopathology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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