NDLI: Activating the Wnt/ß-Catenin Pathway Did Not Protect Immature Retina from Hypoxic-Ischemic Injury.

Please wait, while we are loading the content...

Year: 2017 Volume: 58

Year: 2016 Volume: 57

Year: 2015 Volume: 56

Year: 2015 Volume: 56 Issue: 13

Year: 2015 Volume: 56 Issue: 12

Year: 2015 Volume: 56 Issue: 11

Year: 2015 Volume: 56 Issue: 10

Year: 2015 Volume: 56 Issue: 9

Year: 2015 Volume: 56 Issue: 8

Long-Term Reproducibility of Macular Ganglion Cell Analysis in Clinically Stable Glaucoma Patients.

RefMoB, a Reflectivity Feature Model-Based Automated Method for Measuring Four Outer Retinal Hyperreflective Bands in Optical Coherence Tomography.

Increased Plasma S100A12 Levels Are Associated With Diabetic Retinopathy and Prognostic Biomarkers of Macrovascular Events in Type 2 Diabetic Patients.

IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells.

Aldose Reductase Mediates Transforming Growth Factor ß2 (TGF-ß2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells.

The Effects of Increasing Ocular Surface Stimulation on Blinking and Tear Secretion.

The Relationship Between Serum 25-Hydroxyvitamin D Levels and Nuclear Cataract in the Carotenoid Age-Related Eye Study (CAREDS), an Ancillary Study of the Women's Health Initiative.

Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment Epithelium.

Measurement of Crystalline Lens Volume During Accommodation in a Lens Stretcher.

Toward New Engagement Paradigms For Intraocular Lenses: Light-Initiated Bonding of Capsular Bag to Lens Materials.

Axonal Transport in the Rat Optic Nerve Following Short-Term Reduction in Cerebrospinal Fluid Pressure or Elevation in Intraocular Pressure.

Foveal Sparing of Reticular Drusen in Eyes With Early and Intermediate Age-Related Macular Degeneration.

Corneal Shape, Volume, and Interocular Symmetry: Parameters to Optimize the Design of Biosynthetic Corneal Substitutes.

Global Visit Effects in Point-Wise Longitudinal Modeling of Glaucomatous Visual Fields.

Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.

Activating the Wnt/ß-Catenin Pathway Did Not Protect Immature Retina from Hypoxic-Ischemic Injury.

Transient Downregulation of Melanopsin Expression After Retrograde Tracing or Optic Nerve Injury in Adult Rats.

Barriers to Follow-Up and Strategies to Improve Adherence to Appointments for Care of Chronic Eye Diseases.

Revalidating the Usefulness of a 'Sector-Wise Regression' Approach to Predict Glaucomatous Visual Function Progression.

A New Recombinant PACAP-Derived Peptide Efficiently Promotes Corneal Wound Repairing and Lacrimal Secretion.

Isolation and Investigation of Presumptive Murine Lacrimal Gland Stem Cells.

Otago Glaucoma Surgery Outcome Study: Further Histology and Immunohistochemistry of Molteno Implant Blebs.

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma.

Crouzon Syndrome: Relationship of Eye Movements to Pattern Strabismus.

Meibum Color and Free Fatty Acid Composition in Patients With Meibomian Gland Dysfunction.

Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina.

Lacrimal Gland Volume Changes in Unilateral Primary Acquired Nasolacrimal Obstruction.

Normal Perceptual Sensitivity Arising From Weakly Reflective Cone Photoreceptors.

A Novel Motion-on-Color Paradigm for Isolating Magnocellular Pathway Function in Preperimetric Glaucoma.

Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix.

Establishment of a Cell Line From Conjunctival Squamous Cell Carcinoma: PeCa-UkHb-01.

Stereo Photo Measured ONH Shape Predicts Development of POAG in Subjects With Ocular Hypertension.

Effects of Different Levels of Refractive Blur on Nighttime Pedestrian Visibility.

Being Conspicuous at Night on a Blurred Road.

Comparison of Retinal Nerve Fiber Layer Thinning and Retinal Ganglion Cell Loss After Optic Nerve Transection in Adult Albino Rats.

Yunnan Minority Eye Study Suggests That Ethnic Differences in Myopia Are Due to Different Environmental Exposures.

Reversible Increase of Central Choroidal Thickness During High-Altitude Exposure.

Multifocal Pupillography Identifies Changes in Visual Sensitivity According to Severity of Diabetic Retinopathy in Type 2 Diabetes.

Central and Peripheral Corneal Power Change in Myopic Orthokeratology and Its Relationship With 2-Year Axial Length Change.

Microsaccades and Prediction of a Motor Act Outcome in a Dynamic Sport Situation.

Expansion of CTG18.1 Trinucleotide Repeat in TCF4 Is a Potent Driver of Fuchs' Corneal Dystrophy.

In Vivo Foveal Development Using Optical Coherence Tomography.

Handheld OCT Comes of Age.

Optic Disc Ovality in Primary School Children in Beijing.

Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell Layer in the Epiretinal Membrane: The Repeatability Study of Optical Coherence Tomography.

Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy.

Gene Expression-Based Predictive Models of Graft Versus Host Disease-Associated Dry Eye.

The Noninflammatory Phenotype of Neutrophils From the Closed-Eye Environment: A Flow Cytometry Analysis of Receptor Expression.

Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a.

Association of Genetic Variations in TNFSF15 With Acute Anterior Uveitis in Chinese Han.

Characterization of Abnormal Optic Nerve Head Morphology in Albinism Using Optical Coherence Tomography.

Autosomal Recessive Bestrophinopathy Is Not Associated With the Loss of Bestrophin-1 Anion Channel Function in a Patient With a Novel BEST1 Mutation.

Visual Prognosis of Eyes Recovering From Macular Hole Surgery Through Automated Quantitative Analysis of Spectral-Domain Optical Coherence Tomography (SD-OCT) Scans.

Development of Animal Models of Local Retinal Degeneration.

Protein Composition of TGFBI-R124C- and TGFBI-R555W-Associated Aggregates Suggests Multiple Mechanisms Leading to Lattice and Granular Corneal Dystrophy.

Objective Analysis of Hyperreflective Outer Retinal Bands Imaged by Optical Coherence Tomography in Patients With Stargardt Disease.

Impact of Macular Pigment on Fundus Autofluorescence Lifetimes.

Using Flickering Light to Enhance Nonimage-Forming Visual Stimulation in Humans.

Bacteria Colonizing the Ocular Surface in Eyes With Boston Type 1 Keratoprosthesis: Analysis of Biofilm-Forming Capability and Vancomycin Tolerance.

Human Umbilical Cord Lining Cells as Novel Feeder Layer for Ex Vivo Cultivation of Limbal Epithelial Cells.

In Vivo and In Vitro Feasibility Studies of Intraocular Use of Polyethylene Glycol-Based Synthetic Sealant to Close Retinal Breaks in Porcine and Rabbit Eyes.

The Association Between Menarche and Myopia: Findings From the Korean National Health and Nutrition Examination, 2008-2012.

Nationwide Incidence of Ocular Melanoma in South Korea by Using the National Cancer Registry Database (1999-2011).

Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration.

Time Outdoors and Myopia Progression Over 2 Years in Chinese Children: The Anyang Childhood Eye Study.

The Influence of Oxygen on the Proliferative Capacity and Differentiation Potential of Lacrimal Gland-Derived Mesenchymal Stem Cells.

Melatonin Entrains PER2::LUC Bioluminescence Circadian Rhythm in the Mouse Cornea.

Lens Shape and Refractive Index Distribution in Type 1 Diabetes.

M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy.

Prevalence of Mitochondrial ND4 Mutations in 1281 Han Chinese Subjects With Leber's Hereditary Optic Neuropathy.

Fluid Dynamics of a Novel Micro-Fistula Implant for the Surgical Treatment of Glaucoma.

Three-Dimensional Morphometric Analysis of the Iris by Swept-Source Anterior Segment Optical Coherence Tomography in a Caucasian Population.

Improving Mobility Performance in Low Vision With a Distance-Based Representation of the Visual Scene.

The Association of Estimated Glomerular Filtration Rate With Diabetic Retinopathy and Macular Edema.

In Vivo Assessment of Pharmacologic Vitreolysis in Rabbits With the Digital Fluoroscopy System.

Birc7: A Late Fiber Gene of the Crystalline Lens.

Influence of Opa1 Mutation on Survival and Function of Retinal Ganglion Cells.

A New Splicing Isoform of Cacna2d4 Mimicking the Effects of c.2451insC Mutation in the Retina: Novel Molecular and Electrophysiological Insights.

Trinucleotide Repeat Expansion in the TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy in Japanese.

Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B.

Sex-Related Differences in Ocular Blood Flow of Healthy Subjects Using Laser Speckle Flowgraphy.

Aqueous Humor Outflow Physiology in NOS3 Knockout Mice.

In Vivo Confocal Microscopy Demonstrates Bilateral Loss of Endothelial Cells in Unilateral Herpes Simplex Keratitis.

Herpes Simplex Keratitis: Bilateral Effects.

Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas.

Transcriptome Profiling of Developing Murine Lens Through RNA Sequencing.

Disc Torsion and Vertical Disc Tilt Are Related to Subfoveal Scleral Thickness in Open-Angle Glaucoma Patients With Myopia.

Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments

Topography of Lymphatic Markers in Human Iris and Ciliary Body.

Complement C5 Gene Confers Risk for Acute Anterior Uveitis.

The Effect of PKC on the Light Response of Rod Bipolar Cells in the Mouse Retina.

Remembering David C. Beebe, PhD, 1944-2015.

Suprachoroidal Drug Delivery: Unique New Observations.

Myocyte Dedifferentiation Drives Extraocular Muscle Regeneration in Adult Zebrafish.

Circadian Intraocular Pressure Fluctuation and Disease Progression in Primary Angle Closure Glaucoma.

Transepithelial Riboflavin Absorption in an Ex Vivo Rabbit Corneal Model.

Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma.

Metabolome-Wide Association Study of Primary Open Angle Glaucoma.

Flecks in Recessive Stargardt Disease: Short-Wavelength Autofluorescence, Near-Infrared Autofluorescence, and Optical Coherence Tomography.

Year: 2015 Volume: 56 Issue: 6

Year: 2015 Volume: 56 Issue: 5

Year: 2015 Volume: 56 Issue: 4

Year: 2015 Volume: 56 Issue: 3

Year: 2015 Volume: 56 Issue: 2

Year: 2015 Volume: 56 Issue: 1

Year: 2014 Volume: 56

Year: 2014 Volume: 55

Year: 2013 Volume: 54

Year: 2012 Volume: 53

Year: 2011 Volume: 52

Year: 2010 Volume: 51

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Activating the Wnt/ß-Catenin Pathway Did Not Protect Immature Retina from Hypoxic-Ischemic Injury.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Huang, Chao-Ching Chang, Ying-Chao Hung, Pi-Liang Wang, Feng-Sheng Huang, Hsiu-Mei
Description	Country affiliation: Taiwan Author Affiliation: Huang HM ( Department of Ophthalmology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.); Huang CC ( Department of Pediatrics, National Cheng Kung University Hospital, Tainan City, Taiwan and Department of Pediatrics, Taipei Medical University, College of Medicine, Taipei, Taiwan.); Wang FS ( Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.); Hung PL ( Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.); Chang YC ( Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.)
Abstract	PURPOSE: Visual loss associated with hypoxic-ischemic (HI) brain damage is the most common cause of visual impairment in children of developed countries. A neuroprotective role for Wnt/ß-catenin signaling has been demonstrated in several neurodegenerative disorders. The association of Wnt signaling with HI injury in immature retina has not been established. METHODS: On postnatal day 7 (P7), HI was induced by unilateral common carotid artery ligation followed by 8% oxygen hypoxia for 2 hours. The pups received intravitreous injection (i.v.i) of PBS, Dickkopf-1 (DKK-1, the negative modulator of Wnt/ß-catenin pathway) antisense (AS) or sense (S) oligonucleotides at various concentrations for pretreatment (24 and 1 hour before HI) or post treatment (1 and 4 hours after HI). For chronic treatments, animals received repeated intraperitoneal (i.p.) injection of DKK-1-AS, DKK-1-S, lithium chloride (LiCl), or vehicles after HI. The retinal injury was assessed by electroretinography (ERG, P21, and P30) and immunohistochemical staining (P8 or P30). RESULTS: Pretreatment with DKK-1-AS (i.v.i.) attenuated DKK-1 and enhanced ß-catenin expression, but did not protect immature retina against HI injury at both pathological and functional levels. Post treatment with DKK-1-AS (i.v.i. or i.p.) also did not rescue HI retinopathy. Chronic systemic LiCl treatment did not decrease Müller cell activation or neuronal damage in HI retinal injury. CONCLUSIONS: Our data demonstrated that DKK-1 inhibition or chronic lithium treatment did not protect the immature retina from HI injury. It is speculated that the enhanced canonical Wnt/ß-catenin signaling is not sufficient to protect the immature retina from HI injury.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	8
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Anoxia Metabolism Retina Wnt Proteins Wnt Signaling Pathway Physiology Beta Catenin Animals Animals, Newborn Blotting, Western Cell Death Disease Models, Animal Electroretinography Pathology Physiopathology Immunohistochemistry In Situ Nick-end Labeling Neurons Rats, Sprague-dawley Signal Transduction Research Support, Non-u.s. Gov't Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in