NDLI: Assessment of cytotoxicity and oxidative stress induced by titanium oxide nanoparticles on Chinook salmon cells.

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Assessment of cytotoxicity and oxidative stress induced by titanium oxide nanoparticles on Chinook salmon cells.

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Assessment of cytotoxicity and oxidative stress induced by titanium oxide nanoparticles on Chinook salmon cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Srikanth, Koigoora Ahmad, Iqbal Pereira, Eduarda Rao, Janapala Venkateswara Duarte, Armando C.
Description	Country affiliation: Portugal Author Affiliation: Srikanth K ( CESAM-Centre for Environmental and Marine Studies & Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. koigooras@ua.pt.); Pereira E ( Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India. koigooras@ua.pt.); Duarte AC ( CESAM-Centre for Environmental and Marine Studies & Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.); Ahmad I ( CESAM-Centre for Environmental and Marine Studies & Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.); Rao JV ( CESAM-Centre for Environmental and Marine Studies & Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal.)
Abstract	Titanium oxide nanoparticles (TiO2 NPs) have received wide attention in diverse application, but the potential impact of these nanomaterials on the environment, aquatic life and especially on fish cell lines is lacking. The present study aimed to investigate the cytotoxicity and oxidative stress induced by TiO2 NPs on Chinook salmon cells derived from Oncorhynchus tshawytscha embryos (CHSE-214). The The MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide] and neutral red (NR) assays in CHSE-214 cells exposed to TiO2 NPs revealed concentration-dependent cytotoxic effect in the range of 10 to 60 µg/ml for 24 h. CHSE-214 cells exposed to TiO2 NPs (10-60 µg/ml) exhibited significant decline in superoxide dismutase (SOD), catalase (CAT) glutathione (GSH) content and increased lipid peroxidation (LPO) in a concentration-dependent manner. TiO2 NPs induced cytotoxicity and oxidative stress in CHSE-214 cells which serve as a base line studies for future studies.
ISSN	09441344
Issue Number	20
Volume Number	22
e-ISSN	16147499
Journal	Environmental Science and Pollution Research
Language	English
Publisher	Springer
Publisher Date	2015-10-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Metal Nanoparticles Toxicity Oxidative Stress Salmon Metabolism Titanium Water Pollutants, Chemical Animals Catalase Cell Line Cell Survival Fish Proteins Glutathione Lipid Peroxidation Drug Effects Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine

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