| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Yang, Yumei Zhang, Lianshuang Shi, Zhixiong Sun, Zhiwei Duan, Junchao Guo, Fangzi Zhou, Xianqing Wei, Jialiu Li, Yanbo |
| Description |
Country affiliation: China Author Affiliation: Zhang L ( Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.); Wei J ( Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.); Guo F ( Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.); Duan J ( Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.); Li Y ( Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.); Shi Z ( Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.); Yang Y ( Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.); Zhou X ( Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.); Sun Z ( Department of Toxicology and Hygienic Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, China.) |
| Abstract |
Endosulfan, a persistent organic pollutant, is widely used in agriculture as a pesticide. The aim of the present study was to evaluate the blood toxicity of different doses of endosulfan in Wistar rats. The experimental sample was composed of four groups, a control group that did not receive endosulfan and three endosulfan-exposed groups that respectively received 1, 5, or 10 mg/kg/day (doses below LD50), of endosulfan for 21 days. The results showed that endosulfan significantly decreased the prothrombin time (PT) and upregulated the activated coagulation factors VIIa, Xa, and XIIIa; thrombin-antithrombin complex (TAT); and P-selectin. Plasma levels of tissue factor (TF) and malondialdehyde (MDA) were increased in the endosulfan groups. The activated partial thromboplastin time (APTT) and the level of activated coagulation factor IXa showed no obvious changes. Immunohistochemical results showed increased expression of von Willebrand factor (vWF) and the inflammatory cytokine interleukin (IL)-1ß in the groups exposed to endosulfan. The pathology and electron microscopy results showed impaired vascular tissue accompanied by the exfoliation of endothelial cells and mitochondrial damage in the endosulfan-exposed groups. In summary, our results suggest that endosulfan damages endothelial cells via oxidative stress and the inflammatory response, leading to the release of TF and vWF into the blood. The TF and vWF in the blood may activate extrinsic coagulation factors and platelets, thus triggering the extrinsic coagulation pathway. There were no obvious effects on the intrinsic coagulation pathway. |
| ISSN |
09441344 |
| Issue Number |
20 |
| Volume Number |
22 |
| e-ISSN |
16147499 |
| Journal |
Environmental Science and Pollution Research |
| Language |
English |
| Publisher |
Springer |
| Publisher Date |
2015-10-01 |
| Publisher Place |
Germany |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Blood Coagulation Drug Effects Endosulfan Toxicity Endothelial Cells Pesticides Animals Antithrombin Iii Metabolism Blood Coagulation Factors Male Oxidative Stress Peptide Hydrolases Rats Rats, Wistar Thromboplastin Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science Discipline Environmental Chemistry |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Environmental Chemistry Health, Toxicology and Mutagenesis Pollution Medicine |
