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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Suman, T. Y. Radhika Rajasree, S. R. Kirubagaran, R. |
| Description | Country affiliation: India Author Affiliation: Suman TY ( Center for Ocean Research (NIOT-SU Collaborative Research Centre), Sathyabama University, Chennai 600119, Tamil Nadu, India.); Radhika Rajasree SR ( Center for Ocean Research (NIOT-SU Collaborative Research Centre), Sathyabama University, Chennai 600119, Tamil Nadu, India. Electronic address: radhiin@gmail.com.); Kirubagaran R ( Marine Biotechnology, ESOO-National Institute of Ocean Technology, OSTI, Pallikaranai, Chennai 600100, India.) |
| Abstract | The increasing industrial use of nanomaterials during the last decades poses a potential threat to the environment and in particular to organisms living in the aquatic environment. In the present study, the toxicity of zinc oxide nanoparticles (ZnO NPs) was investigated in Marine algae Chlorella vulgaris (C. vulgaris). High zinc dissociation from ZnONPs, releasing ionic zinc in seawater, is a potential route for zinc assimilation and ZnONPs toxicity. To examine the mechanism of toxicity, C. vulgaris were treated with 50mg/L, 100mg/L, 200mg/L and 300 mg/L ZnO NPs for 24h and 72h. The detailed cytotoxicity assay showed a substantial reduction in the viability dependent on dose and exposure. Further, flow cytometry revealed the significant reduction in C. vulgaris viable cells to higher ZnO NPs. Significant reductions in LDH level were noted for ZnO NPs at 300 mg/L concentration. The activity of antioxidant enzyme superoxide dismutase (SOD) significantly increased in the C. vulgaris exposed to 200mg/L and 300 mg/L ZnO NPs. The content of non-enzymatic antioxidant glutathione (GSH) significantly decreased in the groups with a ZnO NPs concentration of higher than 100mg/L. The level of lipid peroxidation (LPO) was found to increase as the ZnO NPs dose increased. The FT-IR analyses suggested surface chemical interaction between nanoparticles and algal cells. The substantial morphological changes and cell wall damage were confirmed through microscopic analyses (FESEM and CM). |
| File Format | HTM / HTML |
| ISSN | 01476513 |
| Volume Number | 113 |
| e-ISSN | 10902414 |
| Journal | Ecotoxicology and Environmental Safety |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Sciences Chlorella Vulgaris Drug Effects Metal Nanoparticles Toxicity Oxidative Stress Zinc Oxide Antioxidants Metabolism Ultrastructure Cytotoxins Flow Cytometry Glutathione Lipid Peroxidation Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pollution Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
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