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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cao, Hung Scianmarello, Nick Zhao, Yu Dai, Wangde Pacella, John Hsiai, Tzung Jen, Nelson Beebe, Tyler Yu, Fei Lee, Juhyun Tai, Yu-Chong Mody, Freny V. Chang, Donald S. Li, Rongsong Ebrahimi, Ramin |
| Description | Country affiliation: United States Author Affiliation: Cao H ( Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States); Yu F ( Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States.); Zhao Y ( Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.); Scianmarello N ( Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.); Lee J ( Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States); Dai W ( The Heart Institute of Good Samaritan Hospital, Los Angeles, CA, United States.); Jen N ( Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States); Beebe T ( Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States); Li R ( Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States); Ebrahimi R ( Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.); Chang DS ( Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.); Mody FV ( Division of Cardiology, Department of Medicine, VA Greater Los Angeles Healthcare System, School of Medicine, University of California, United States.); Pacella J ( Division of Cardiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.); Tai YC ( Department of Electrical Engineering, California Institute of Technology, Pasadena, CA, United States.); Hsiai T ( Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States) |
| Abstract | Flexible electronics have enabled catheter-based intravascular sensing. However, real-time interrogation of unstable plaque remains an unmet clinical challenge. Here, we demonstrate the feasibility of stretchable electrochemical impedance spectroscopy (EIS) sensors for endoluminal investigations in New Zealand White (NZW) rabbits on diet-induced hyperlipidemia. A parylene C (PAC)-based EIS sensor mounted on the surface of an inflatable silicone balloon affixed to the tip of an interrogating catheter was deployed (1) on the explants of NZW rabbit aorta for detection of lipid-rich atherosclerotic lesions, and (2) on live animals for demonstration of balloon inflation and EIS measurements. An input peak-to-peak AC voltage of 10 mV and sweeping-frequency from 300 kHz to 100 Hz were delivered to the endoluminal sites. Balloon inflation allowed EIS sensors to be in contact with endoluminal surface. In the oxidized low-density-lipoprotein (oxLDL)-rich lesions from explants of fat-fed rabbits, impedance magnitude increased significantly by 1.5-fold across the entire frequency band, and phase shifted ~5° at frequencies below 10 kHz. In the lesion-free sites of the normal diet-fed rabbits, impedance magnitude increased by 1.2-fold and phase shifted ~5° at frequencies above 30 kHz. Thus, we demonstrate the feasibility of stretchable intravascular EIS sensors for identification of lipid rich lesions, with a translational implication for detecting unstable lesions. |
| ISSN | 09565663 |
| e-ISSN | 18734235 |
| DOI | 10.1016/j.bios.2013.11.059 |
| Journal | Biosensors and Bioelectronics |
| Volume Number | 54 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-04-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Aorta Pathology Atherosclerosis Diagnosis Biosensing Techniques Instrumentation Dielectric Spectroscopy Lipids Plaque, Atherosclerotic Animals Electric Impedance Equipment Design Lipoproteins, Ldl Rabbits Research Support, N.i.h., Extramural Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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