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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Laurand, Nicolas Burley, Glenn A. Skabara, Peter J. Haughey, Anne-Marie Kanibolotsky, Alexander L. Dawson, Martin D. Guilhabert, Benoit |
| Description | Author Affiliation: Haughey AM ( Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: annemarie.haughey@strath.ac.uk.); Guilhabert B ( Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: benoit.guilhabert@strath.ac.uk.); Kanibolotsky AL ( WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. Electronic address: alexander.kanibolotsky@strath.ac.uk.); Skabara PJ ( WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. Electronic address: peter.skabara@strath.ac.uk.); Dawson MD ( Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: m.dawson@strath.ac.uk.); Burley GA ( WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK. Electronic address: glenn.burley@strath.ac.uk.); Laurand N ( Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, UK. Electronic address: nicolas.laurand@strath.ac.uk.) |
| Abstract | The first example of an all-organic oligofluorene truxene based distributed feedback laser for the detection of a specific protein-small molecule interaction is reported. The protein avidin was detected down to 1 µg mL(-1) using our biotin-labelled biosensor platform. This interaction was both selective and reversible when biotin was replaced with desthiobiotin. Avidin detection was not perturbed by Bovine Serum Albumin up to 50,000 µg mL(-1). Our biosensor offers a new detection platform that is both highly sensitive, modular and potentially re-usable. |
| ISSN | 09565663 |
| Volume Number | 54 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-04-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Avidin Analysis Metabolism Biosensing Techniques Instrumentation Biotin Fluorenes Chemistry Lasers Animals Analogs & Derivatives Biotinylation Cattle Equipment Design Semiconductors Sensitivity And Specificity Serum Albumin, Bovine Evaluation Studies Journal Article Research Support, Non-u.s. Gov't Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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