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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Deng, Sheng-Yuan Yuan, Pei-Xin Wan, Ying Cosnier, Serge Yao, Chuan-Guang Shan, Dan |
| Description | Author Affiliation: Yuan PX ( Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094 China.); Deng SY ( Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094 China. Electronic address: sydeng@njust.edu.cn.); Yao CG ( Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094 China.); Wan Y ( Intelligent Microsystem Technology and Engineering Center, School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, 210094 China.); Cosnier S ( Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094 China); Shan D ( Sino-French Laboratory of Biomaterials and Bioanalytical Chemistry, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094 China. Electronic address: danshan@njust.edu.cn.) |
| Abstract | A highly efficient surface plasmon resonance (SPR)-based DNA assay was developed, by employing noncovalently functionalized graphene nanosheets as a substrate, and enzymatic catalysis-induced polymerization as mass relay. The objective of this strategy was manifold: first of all, to sensitize the overall SPR output by in situ optimized electrogeneration of graphene thin-film, which was characterized by atomic force microscopic topography; secondly, to regulate the self-assembly and orientation of biotinylated capture probes on nickel-chelated nitrilotriacetic acid (NTA) scaffolds, that anchored onto graphene-supported pyrenyl derivatives; and lastly, to synergize the signal amplification via real-time conversion of the additive aniline into polyaniline precipitation by horseradish peroxidase-tagged reporters. With this setup, a precise and replicable DNA sensing platform for specific targets was achieved with a detection limit down to femtomolar, thus demonstrating a beneficial exploration and exploitation of two-dimensional nanomaterials as unique SPR infrastructure. The possibility of such â ³bottom-upâ ³ architecture mounted with â ³top-downâ ³ weight reactor would be most likely extensible and adaptable to protein determinations. |
| ISSN | 09565663 |
| Issue Number | Pt 1 |
| Volume Number | 89 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-03-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Dna Analysis Graphite Chemistry Nanostructures Surface Plasmon Resonance Methods Aniline Compounds Biotinylation Horseradish Peroxidase Immobilized Nucleic Acids Limit Of Detection Ultrastructure Oxidation-reduction Oxides Polymerization Journal Article Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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