NDLI: The application of graphene for in vitro and in vivo electrochemical biosensing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Taboada Sotomayor, Maria Del Pilar Janegitz, Bruno Campos Vicentini, Fernando Campanhã Silva, Tiago Almeida Wong, Ademar Fatibello-Filho, Orlando Ribovski, Laís
Description	Author Affiliation: Janegitz BC ( Department of Nature Sciences, Mathematics and Education, Federal University of São Carlos, 13600-970 Araras, SP, Brazil. Electronic address: brunocj@ufscar.br.); Silva TA ( Department of Chemistry, Federal University of São Carlos, 13565-970 São Carlos, SP, Brazil.); Wong A ( Department of Chemistry, Federal University of São Carlos, 13565-970 São Carlos, SP, Brazil.); Ribovski L ( Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, 13560-970 São Carlos, SP, Brazil.); Vicentini FC ( Center of Nature Sciences, Federal University of São Carlos, 18290-000 Buri, SP, Brazil.); Taboada Sotomayor MD ( Department of Analytical Chemistry, Institute of Chemistry, State University of São Paulo, 14800-060 Araraquara, SP, Brazil.); Fatibello-Filho O ( Department of Chemistry, Federal University of São Carlos, 13565-970 São Carlos, SP, Brazil.)
Abstract	Advances in analysis are required for rapid and reliable clinical diagnosis. Graphene is a 2D material that has been extensively used in the development of devices for the medical proposes due to properties such as an elevated surface area and excellent electrical conductivity. On the other hand, architectures have been designed with the incorporation of different biological recognition elements such as antibodies/antigens and DNA probes for the proposition of immunosensors and genosensors. This field presents a great progress in the last few years, which have opened up a wide range of applications. Here, we highlight a rather comprehensive overview of the interesting properties of graphene for in vitro, in vivo, and point-of-care electrochemical biosensing. In the course of the paper, we first introduce graphene, electroanalytical methods (potentiometry, voltammetry, amperometry and electrochemical impedance spectroscopy) followed by an overview of the prospects and possible applications of this material in electrochemical biosensors. In this context, we discuss some relevant trends including the monitoring of multiple biomarkers for cancer diagnostic, implantable devices for in vivo sensing and, development of point-of-care devices to real-time diagnostics.
ISSN	09565663
Issue Number	Pt 1
Volume Number	89
e-ISSN	18734235
Journal	Biosensors and Bioelectronics
Language	English
Publisher	Elsevier
Publisher Date	2017-03-15
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biosensing Techniques Methods Electrochemical Techniques Graphite Chemistry Nanostructures Point-of-care Systems Animals Biological Markers Analysis Instrumentation Equipment Design Humans Models, Molecular Ultrastructure Neoplasms Diagnosis Journal Article Review Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry

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