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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Long Li, Can-Peng Zhang, Yanqiong Zhao, Hui Ran, Xin Li, Yucong Liu, Feng Zhao, Genfu Ye, Hanzhang |
| Description | Author Affiliation: Zhao H ( State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, PR China.); Yang L ( School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.); Li Y ( School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.); Ran X ( School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.); Ye H ( School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.); Zhao G ( School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.); Zhang Y ( School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.); Liu F ( State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, PR China.); Li CP ( School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address: lcppp1974@sina.com.) |
| Abstract | The present work described the comparison of ß-cyclodextrin (ß-CD) and p-sulfonated calix[6]arene (SCX6) functionalized reduced graphene oxide (RGO) for recognition of tadalafil. In this study, tadalafil and two macrocycles (ß-CD and SCX6) were selected as the guest and host molecules, respectively. The inclusion complexes of ß-CD/tadalafil and SCX6/tadalafil were studied by UV spectroscopy and molecular simulation calculations, proving the higher supermolecular recognition capability of SCX6 than ß-CD towards tadalafil. The ß-CD@RGO and SCX6@RGO composites were prepared by a wet-chemical route. The obtained composites were characterized by Fourier transform infrared spectrometry, thermogravimetric analysis, atomic force microscopy, and zeta potential. The SCX6@RGO showed a higher electrochemical response than ß-CD@RGO, which was caused by the higher recognition capability of SCX6 than ß-CD. By combining the merits of SCX6 and the RGO, a sensitive electrochemical sensing platform was developed based on the SCX6@RGO nanohybrids. A linear response range of 0.1-50 µM and 50-1000 µM for tadalafil with a low detection limit of 0.045 µM (S/N=3) was obtained by using this method. The constructed sensing platform was successfully used to determine tadalafil in herbal sexual health products and spiked human serum samples, suggesting its promising analytical applications for the trace level determination of tadalafil. |
| ISSN | 09565663 |
| Issue Number | Pt 1 |
| Volume Number | 89 |
| e-ISSN | 18734235 |
| Journal | Biosensors and Bioelectronics |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-03-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Calixarenes Chemistry Electrochemical Techniques Methods Graphite Phenols Tadalafil Blood Vasodilator Agents Beta-cyclodextrins Biosensing Techniques Humans Limit Of Detection Models, Molecular Molecular Docking Simulation Oxidation-reduction Oxides Plants, Medicinal Sulfones Analysis Comparative Study Evaluation Studies Journal Article Discipline Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry |
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