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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fernández-fernández, José M. Andrade, Yaniré N. Sánchez, Trinidad M. Vázquez, Esther Villalón, Manuel Fernandes, Jacqueline Arniges, Maite Valverde, Miguel A. |
| Description | Author Affiliation: Andrade YN ( Grup de Fisiologia Cellular i Molecular, Unitat de Senyalització Cellular, Universitat Pompeu Fabra, Barcelona 08003, Spain.) |
| Abstract | Autoregulation of the ciliary beat frequency (CBF) has been proposed as the mechanism used by epithelial ciliated cells to maintain the CBF and prevent the collapse of mucociliary transport under conditions of varying mucus viscosity. Despite the relevance of this regulatory response to the pathophysiology of airways and reproductive tract, the underlying cellular and molecular aspects remain unknown. Hamster oviductal ciliated cells express the transient receptor potential vanilloid 4 (TRPV4) channel, which is activated by increased viscous load involving a phospholipase $A_{2}–dependent$ pathway. TRPV4-transfected HeLa cells also increased their cationic currents in response to high viscous load. This mechanical activation is prevented in native ciliated cells loaded with a TRPV4 antibody. Application of the TRPV4 synthetic ligand 4α-phorbol 12,13-didecanoate increased cationic currents, intracellular $Ca^{2+},$ and the CBF in the absence of a viscous load. Therefore, TRPV4 emerges as a candidate to participate in the coupling of fluid viscosity changes to the generation of the $Ca^{2+}$ signal required for the autoregulation of CBF. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 168 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2005-03-14 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cation Transport Proteins Physiology Epithelial Cells Ion Channels Animals Blotting, Western Calcium Metabolism Genetics Cells, Cultured Cricetinae Cytosol Chemistry Dextrans Pharmacology Dose-Response Relationship, Drug Cytology Fallopian Tubes Gadolinium HeLa Cells Kinetics Ligands Mechanotransduction, Cellular Mesocricetus Microscopy, Confocal Patch-Clamp Techniques Phorbol Esters Phospholipases A TRPV Cation Channels Time Factors Viscosity Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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