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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bai, Jihong Chapman, Edwin R. Richards, David A. |
| Description | Author Affiliation: Richards DA ( Department of Physiology, University of Wisconsin-Madison, Madison, WI 53706, USA.) |
| Abstract | We have examined the kinetics by which FM1-43 escapes from individual synaptic vesicles during exocytosis at hippocampal boutons. Two populations of exocytic events were observed; small amplitude events that lose dye slowly, which made up more than half of all events, and faster, larger amplitude events with a fluorescence intensity equivalent to single stained synaptic vesicles. These populations of destaining events are distinct in both brightness and kinetics, suggesting that they result from two distinct modes of exocytosis. Small amplitude events show tightly clustered rate constants of dye release, whereas larger events have a more scattered distribution. Kinetic analysis of the association and dissociation of FM1-43 with membranes, in combination with a simple pore permeation model, indicates that the small, slowly destaining events may be mediated by a narrow ∼1-nm fusion pore. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 168 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2005-03-14 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Exocytosis Fluorescent Dyes Hippocampus Physiology Pyridinium Compounds Quaternary Ammonium Compounds Synapses Synaptic Vesicles Metabolism Animals Animals, Newborn Antibodies, Monoclonal Calcium-Binding Proteins Cells, Cultured Dose-Response Relationship, Drug Pharmacology Cytology Kinetics Liposomes Melitten Membrane Glycoproteins Membrane Proteins Mice Models, Biological Models, Neurological Nerve Tissue Proteins Precipitin Tests Presynaptic Terminals R-SNARE Proteins Receptors, N-Methyl-D-Aspartate Synaptotagmins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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