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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yamada, Eijiro Saito, Tsugumichi Mori, Masatomo Sato, Minoru Okada, Shuichi Uehara, Yutaka Ohshima, Kihachi Tsuchiya, Takafumi Shimizu, Hiroyuki |
| Description | Author Affiliation: Yamada E ( Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan.) |
| Abstract | We have identified an unusual potential dual Akt/protein kinase B consensus phosphorylation motif in the protein Synip $(RxKxRS^{97}xS^{99}).$ Surprisingly, serine 97 is not appreciably phosphorylated, whereas serine 99 is only a specific substrate for Akt2 but not Akt1 or Akt3. Although wild-type Synip (WT-Synip) undergoes an insulin-stimulated dissociation from Syntaxin4, the Synip serine 99 to phenylalanine mutant (S99F-Synip) is resistant to Akt2 phosphorylation and fails to display insulin-stimulated Syntaxin4 dissociation. Furthermore, overexpression of WT-Synip in 3T3L1 adipocytes had no effect on insulin-stimulated recruitment of glucose transporter 4 (GLUT4) to the plasma membrane, whereas overexpression of S99F-Synip functioned in a dominant-interfering manner by preventing insulin-stimulated GLUT4 recruitment and plasma membrane fusion. These data demonstrate that insulin activation of Akt2 specifically regulates the docking/fusion step of GLUT4-containing vesicles at the plasma membrane through the regulation of Synip phosphorylation and Synip–Syntaxin4 interaction. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 168 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2005-03-14 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Membrane Fusion Monosaccharide Transport Proteins Metabolism Muscle Proteins Protein-Serine-Threonine Kinases Proto-Oncogene Proteins Transport Vesicles Vesicular Transport Proteins 3T3 Cells Adipocytes Drug Effects Animals Antibodies, Monoclonal Blotting, Western CHO Cells Cricetinae Cricetulus Deoxyglucose Glucose Transporter Type 4 Green Fluorescent Proteins Insulin Kinetics Mice Microscopy, Confocal Phosphorylation Precipitin Tests Proto-Oncogene Proteins C-akt Time Factors Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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