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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schinke, Thorsten Schmidt, Katy Schilling, Arndt F. Mueldner, Cordula Rueger, Johannes M. Amling, Michael Haberland, Michael Wegner, Michael Sock, Elisabeth Priemel, Matthias |
| Description | Author Affiliation: Schmidt K ( Institute of Biochemistry, Friedrich-Alexander-University, Erlangen-Nürnberg, Erlangen 91054, Germany.) |
| Abstract | Bone remodeling is an important physiologic process that is required to maintain a constant bone mass. This is achieved through a balanced activity of bone-resorbing osteoclasts and bone-forming osteoblasts. In this study, we identify the high mobility group transcription factor Sox8 as a physiologic regulator of bone formation. Sox8-deficient mice display a low bone mass phenotype that is caused by a precocious osteoblast differentiation. Accordingly, primary osteoblasts derived from these mice show an accelerated mineralization ex vivo and a premature expression of osteoblast differentiation markers. To confirm the function of Sox8 as a negative regulator of osteoblast differentiation we generated transgenic mice that express Sox8 under the control of an osteoblast-specific Col1a1 promoter fragment. These mice display a severely impaired bone formation that can be explained by a strongly reduced expression of runt-related transcription factor 2, a gene encoding a transcription factor required for osteoblast differentiation. Together, these data demonstrate a novel function of Sox8, whose tightly controlled expression is critical for bone formation. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 168 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2005-03-14 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation DNA-Binding Proteins Deficiency Gene Expression Regulation, Developmental High Mobility Group Proteins Osteoblasts Cytology Transcription Factors Animals Animals, Newborn Bone Diseases, Metabolic Genetics Bone And Bones Metabolism Calcification, Physiologic Cell Proliferation Cells, Cultured Physiology Enzyme-Linked Immunosorbent Assay Immunohistochemistry In Situ Hybridization Mice Mice, Transgenic Promoter Regions, Genetic Radiography SOXE Transcription Factors Staining And Labeling Transcription Factor AP-2 Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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