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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Eisen, H. Emery, R. Bach, R. |
| Abstract | The presence and accumulation in murine erythroleukemic cells transformed by Friend virus of the erythrocyte membrane-associated protein spectrin has been investigated. Spectrin was present in the uninduced cells and was induced 10- to 20-fold in dimethyl sulfoxide-treated differentiating cells. The intracellular concentration of spectrin reached a peak on the third day of dimethyl sulfoxide treatment, after which it fell to levels found in mouse erythrocytes. We also found that the small subunit of spectrin was phosphorylated in the cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 9 |
| Volume Number | 74 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1977-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Transformation, Viral Friend Murine Leukemia Virus Leukemia, Erythroblastic, Acute Metabolism Membrane Proteins Biosynthesis Spectrin Animals Cell Differentiation Drug Effects Cell Line Dimethyl Sulfoxide Pharmacology Mast-Cell Sarcoma Mice Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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