NDLI: Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1977 Volume: 74 Issue: 12

Year: 1977 Volume: 74 Issue: 11

Year: 1977 Volume: 74 Issue: 10

Year: 1977 Volume: 74 Issue: 9

Synthesis of a fibrinolytic activator and inhibitor by endothelial cells.

31P nuclear magnetic resonance kinetic measurements on adenylatekinase.

Coupling in cytochrome c oxidase

Nucleotide sequences of ribosome recgonition sites in messenger RNAs of vesicular stomatitis virus.

Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A).

Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.

Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.

Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.

Single-stranded DNA from oncornavirus-infected cells enriched in virus-specific DNA sequences.

High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase.

Purification of simian virus 40 tumor antigen from a line of simian virus 40-transformed human cells.

Enzyme regulation in neuroblastoma cells in a salts/glucose medium: induction of ornithine decarboxylase by asparagine and glutamine.

Interaction of L-alpha-didecanoyl phosphatidylcholine with the AI polypeptide of high density lipoprotein.

Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNA.

Fundamental aspects of electron transfer: experimental verification of vibronically coupled electron tunneling.

X-ray absorption edge studies on oxidized and reduced cytochrome c oxidase.

Electron paramagentic resonance studies of photosynthetic electron transport: photoreduction of ferredoxinand membrane-bound iron-sulfur centers.

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts.

Synthesis of collagen by chondrocytes in suspension culture: Modulation by calcium, 3′:5′-cyclic AMP, and prostaglandins

Division of BALB/c mouse 3T3 and simian virus 40-transformed 3T3 cells in cellular aggregates.

Cell fusion induced by herpes simplex virus is promoted and suppressed by different viral glycoproteins.

Amyloid protein SAA is associated with high density lipoprotein from human serum.

Specific receptors for des-Asp1-angiotensin II (('angiotensin III') in rat adrenals.

Alteration of cellular adhesion by nerve growth factor.

Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides.

Purification and properties of human erythrocyte pyrimidine 5'-nucleotidase.

Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

Kinetics of the alkaline tetramer leads to dimer dissociation in liganded human hemoglobin: a laser light-scattering stopped-flow study.

Theoretical study of the effect of enzyme-enzyme interactions on steady-state enzyme kinetics.

Evidence for pro-beta-nerve growth factor, a biosynthetic precursor to beta-nerve growth factor.

DNA packaging and the pathway of bacteriophage T4 head assembly.

Isolation of an electrogenic K+/Ca2+ ionophore from an ionophoroprotein of beef heart mitochondria.

Antibodies to estrogen receptor: immunochemical similarity of estrophilin from various mammalian species.

Role of ribothymidine in mammalian tRNAPhe.

Primary structure of the membranous segment of cytochrome b5.

Animal cell mutants defective in sterol metabolism: a specific selection procedure and partial characterization of defects.

Antipain and leupeptin restrict uterine DNA synthesis and function in mice.

5'-Terminal capping of RNA by guanylyltransferase from HeLa cell nuclei.

Transfer of mannose from mannosyl retinyl phosphate to protein.

3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase

Arrangement of subunits in assembled histone H4 fibers.

Ultrastructural localization of cell membrane GM1 ganglioside by cholera toxin.

Binding of mouse interferon to polynucleotides.

Prescence of tadpole and adult globin RNA sequences in oocytes of Xenopus laevis.

Temporal sequence of hormonal interactions during the prereplicative phase of quiescent cultured 3T3 fibroblasts.

Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit the synthesis of a brain-specific protein in rat glial cells.

Separation and infectivity of circular and linear forms of potato spindle tuber viroid.

Low-molecular-weight peptide inhibits RNA synthesis in human leukemic and phytohemagglutinin-stimulated leukocytes and globin mRNA transcription in differentiating Friend cells.

Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin.

Intracellular distributions of mechanochemical proteins in cultured fibroblasts.

Loss of growth control and differentiation in the fu-1 variant of the L8 line of rat myoblasts.

Morphological differentiation of neuroblastoma cells in medium supplemented with delipidated serum.

Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor.

Stable association of the human transgenome and host murine chromosomes demonstrated with trispecific microcell hybrids.

Rapid speciation and chromosomal evolution in mammals.

Overexpression of an unstably inherited gene in cultured mouse cells.

Heterogeneity of nephritic factor and its identification as an immunoglobulin.

Antibodies to tubulin in normal nonimmunized animals.

Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid.

Active touch exploration of extrapersonal space elicits specific electrogenesis in the right cerebral hemisphere of intact right-handed man.

Neurophysin biosynthesis in normal rats and in rats with hereditary diabetes insipidus.

Effectof MgATP on stiffness measured at two frequencies in Ca2+-activated muscle fibers.

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.

beta-Endorphin: development of tolerance and its reversal by 5-hydroxytryptophan in cats.

Transport of alpha-amylase across the basolateral membrane of the pancreatic acinar cell.

Mutator action by Escherichia coli strains carrying dnaE mutations.

Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro.

Electron microscope studies of transient complexes formed between Escherichia coli RNA polymerase holoenzyme and T7 DNA.

Ligand-promoted weakening of intersubunit bonding domains in aspartate transcarbamolylase.

Cell cycle of Saccharomycescerevisiae in populations growing at different rates.

Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.

Terminus region of the chromosome in Escherichia coli inhibits replication forks.

Involvement of DNA-dependent RNA polymerase in a recA-independent pathway of genetic recombination in Escheria coli.

Role of mitotic replication genes in chromosome duplication during meiosis.

Excision of F plasmid sequences by recombination at directly repeated insertion sequence 2 elements: involvement of recA.

Specialized transducing phage for the initiation factor 3 gene in Escherichia coli.

Intracellular distribution of terminal deoxynucleotidyl transferase in rat bone marrow and thymus.

Interaction of coagulation factor Xa with human platelets.

Extraction of an actin-like protein from the prokaryote Mycoplasma pneumoniae.

Ultrastructural identification of substance P cells and their processes in rat sensory ganglia and their terminals in the spinal cord by immunocytochemistry.

Neurotensin: immunohistochemical localization in rat central nervous system.

Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets.

Secondary structure of heterogeneous nuclear RNA: two classes of double-stranded RNA in native ribonucleoprotein.

New detection of brain dopamine receptors with (3H)dihydroergocryptine.

Occurrence of a major protein associated with fruiting body development in Neurospora and related Ascomycetes.

Induction of spectrin in erythroleukemic cells transformed by Friend virus.

Potentiation of a primary in vivo antibody response by alloantisera against gene products of the I region of the H-2 complex.

Further structural studies of the heavy chain of HLA antigens and its similarity to immunoglobulins.

Histopathogenesis of 7,12-diemthylbenz(a)anthracene-induced rat mammary tumors.

Action potentials occur in cells of the normal anterior pituitary gland and are stimulated by the hypophysiotropic peptide thyrotropin-releasing hormone.

Molecular events and energy changes during the action potential.

Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia.

Key antigenic determinants in regulation of the immune response.

A postsynthetic modification of human alpha-fetoprotein controls its immunosuppressive potency.

Expression of Ia-like antigen molecules on human granulocytes during early phases of differentiation.

Year: 1977 Volume: 74 Issue: 8

Year: 1977 Volume: 74 Issue: 7

Year: 1977 Volume: 74 Issue: 6

Year: 1977 Volume: 74 Issue: 5

Year: 1977 Volume: 74 Issue: 4

Year: 1977 Volume: 74 Issue: 3

Year: 1977 Volume: 74 Issue: 2

Year: 1977 Volume: 74 Issue: 1

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Slaga, T. J. Patterson, E. Yuspa, S. H. Hennings, H. Lichti, U. Ben, T.
Abstract	12-O-Tetradecanoyl phorbol-13-acetate (TPA), a tumor promoter, stimulates DNA synthesis in mouse epidermal cells in vivo and in vitro. This response appears to be mediated through polyamine metabolism because ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17)activity is markedly increased shortly after promoter exposure and this induction varies in magnitude according to dose and promoter potency of a series of phorbol esters. In vitro, exogenous putrescine (0.01-10 mM) results in a dose-related increase and prolongation of promoter-stimulated DNA DNA synthesis, a phenomenon noted in other systems of polyamine-mediated growth stimulation. The anti-inflammatory steroid fluocinolone acetonide (FA), an inhibitor of tumor promotion, prevents TPA stimulation of epidermal proliferation in vivo and in vitro. In vitro, FA most effectively prevents stimulation of DNA synthesis when applied is not required. Paradoxially, FA potentiates the increase in ornithine decarboxylase activity after TPA administeration both in vivo and in vitro. Furthermore, the inhibition of TPA-stimulated DNA synthesis by FA in vitro can be reversed by exogenous putrescine. These results suggestthat FA exerts its antipromotion effect by reducing the sensitivity of the cell to polyamines or by reducing intracellular polyamine levels.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	74
Language	English
Publisher	National Academy of Sciences
Publisher Date	1977-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carboxy-Lyases Metabolism DNA Biosynthesis Fluocinolone Acetonide Pharmacology Ornithine Decarboxylase Skin Animals Cells, Cultured DNA Replication Drug Effects Enzyme Activation Kinetics Mice Putrescine Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in