NDLI: Differentiation in erythroleukemic cells and their somatic hybrids.

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Differentiation in erythroleukemic cells and their somatic hybrids.

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Differentiation in erythroleukemic cells and their somatic hybrids.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Orkin, S. H. Leder, P. Harosi, F. I.
Abstract	Clones of erythroleukemic cells differ in the extent to which they (1) undergo differentiation spontaneously and (2) can be induced to differentiate in the presence of dimethylsulfoxide. Here we demonstrate that relative differences in globin gene expression within and between clones largely reflect differences in the proportion of cells participating in differentiation rather than uniform differences in the extent to which all cells in these clones undergo differentiation. We call this phenotype of a clone its characteristic probability of differentiation, a property that reflects the likelihood that a cell of this clone will undergo erythrodifferentiation under given conditions. We have examined somatic hybrid cells formed between similar erythroleukemic lines, between phenotypically different erythroleukemic lines, between phenotypically different erythroleukemic lines, and between erythroleukemic cells and mouse fibroblasts. Results of these experiments demonstrate that the spontaneous and induced probabilities of differentiation may be altered in an uncoupled fashion, suggesting that each is determined at different steps leading to a common pathway of globin gene expression.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	72
Language	English
Publisher	National Academy of Sciences
Publisher Date	1975-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Globins Biosynthesis Hybrid Cells Metabolism Leukemia, Erythroblastic, Acute Phenotype Animals Cell Differentiation Cell Line Cell Transformation, Neoplastic Clone Cells Dimethyl Sulfoxide Fibroblasts Friend Murine Leukemia Virus Genes Genetics Mice Nucleic Acid Hybridization Parainfluenza Virus 1, Human RNA, Messenger RNA, Neoplasm RNA, Viral Spectrophotometry Transcription, Genetic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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