NDLI: A human soluble suppressor factor affecting lymphocyte responses in vitro.

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Identification of the slow reacting substances from cat paws.

Products of reaction catalyzed by purified rat liver guanylate cyclase determined by 31p NMR spectroscopy.

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Direct observation of the torsional dynamics of DNA and RNA by picosecond spectroscopy.

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A human soluble suppressor factor affecting lymphocyte responses in vitro.

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A human soluble suppressor factor affecting lymphocyte responses in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shou, L. Schwartz, S. A. Chen, C. L. Good, R. A. Peng, R.
Abstract	A soluble suppressor factor (SSF) has been demonstrated in the supernatant of normal human peripheral blood lymphocyte cultures that exhibits suppressive activity toward the proliferative response of normal lymphocytes to concanavalin A or alloantigens in mixed lymphocyte culture (MLC) or toward pokeweed mitogen-stimulated immunoglobulin synthesis and secretion in vitro. Suppression of the proliferative response in MLC reached maximal levels when added SSF-containing supernatant approximated 20% by volume of the culture medium. Suppression in the MLC was found to act at the proliferative stage. SSF acts independently of cytotoxicity and is stable at 56 degrees C for 30 min but is inactivated at higher temperatures. Addition of SSF to the MLC as late as day 4 after initiation of the culture results in suppression of transformation. This factor(s) may regulate the magnitude of several immune responses in humans.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	77
Language	English
Publisher	National Academy of Sciences
Publisher Date	1980-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Immune Tolerance Lymphocytes Immunology Lymphokines Pharmacology T-Lymphocytes, Regulatory Antibody Formation Drug Effects Cells, Cultured Cytotoxicity, Immunologic Lymphocyte Activation Lymphocyte Culture Test, Mixed Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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