NDLI: Platelet-derived growth factor stimulates low density lipoprotein receptor activity in cultured human fibroblasts.

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Products of reaction catalyzed by purified rat liver guanylate cyclase determined by 31p NMR spectroscopy.

Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin.

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Rate-limiting steps in RNA chain initiation.

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NH2-terminal amino acid sequence of human fibroblast interferon.

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Elongation of primed DNA templates by eukaryotic DNA polymerases.

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Platelet-derived growth factor stimulates low density lipoprotein receptor activity in cultured human fibroblasts.

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Platelet-derived growth factor stimulates low density lipoprotein receptor activity in cultured human fibroblasts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Witte, L. D. Cornicelli, J. A.
Abstract	Human platelets contain a mitogen, the platelet-derived growth factor (PDGF), that stimulates the proliferation of a variety of cell types in culture and that may play a role in atherogenesis. Studies were conducted to explore the effects of PDGF on low density lipoprotein (LDL) receptor activity of cultured human fibroblasts. The PDGF utilized in these studies was partially purified from human platelet-rich plama by ion exchange chromatography and gel filtration. LDL receptor activity was assessed by both specific binding of 125I-labeled LDL to the fibroblast's surface at 4 degrees C, and the incorporation of [14C]oleate into cholesteryl esters. Exposure of normal human fibroblasts to increasing amounts of PDGF (0.1-10 microgram/ml) for 48 hr caused a dose-related increase in 125I-labeled LDL binding to a maximum of approximately 300%. In the presence of added LDL, this increase in LDL binding was not seen. Cholesterol esterifiction was also stimulated following a 48-hr exposure to PDGF. Following a conditioning period in LDL- and PDGF-depleted medium, cholesterol esterification was greatly increased during a 48-hr exposure to LDL alone; a smaller but significant increase occurred with PDGF alone. However, both PDGF and LDL were required to return the level of esterification to that observed with whole human serum. Fibroblasts from a patient with homozygous familial hypercholesterolemia, which lack the LDL receptor, also showed a significant increase in cholesteol esterification with PDGF alone, whereas LDL had no effect. These studies demonstrate that PDGF can stimulate the LDL receptor activity in cultured human fibroblasts. The effect on other related activities of the LDL receptor system and the mechanism involved remain to be defined.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	77
Language	English
Publisher	National Academy of Sciences
Publisher Date	1980-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Platelets Physiology Growth Substances Pharmacology Lipoproteins, LDL Metabolism Peptides Receptors, Cell Surface Cells, Cultured Cholesterol Esters Biosynthesis Dose-Response Relationship, Drug Mitogens Platelet-Derived Growth Factor Receptors, LDL Stimulation, Chemical Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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