NDLI: Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents.

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Identification of the slow reacting substances from cat paws.

Products of reaction catalyzed by purified rat liver guanylate cyclase determined by 31p NMR spectroscopy.

Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin.

Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway.

Complementation of arylsulfatase A in somatic hybrids of metachromatic leukodystrophy and multiple sulfatase deficiency disorder fibroblasts.

Synthesis and biological actions of prosomatostatin.

Immunoreactive dynorphin in pituitary and brain.

Catecholamine biosynthetic enzymes are expressed in replicating cells of the peripheral but not the central nervous system.

Direct observation of the torsional dynamics of DNA and RNA by picosecond spectroscopy.

Rate-limiting steps in RNA chain initiation.

5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.

NH2-terminal amino acid sequence of human fibroblast interferon.

Variations in properties of virus released from morphologically different cell lines transformed in vitro by Friend leukemia virus.

Elongation of primed DNA templates by eukaryotic DNA polymerases.

Progesterone inhibition of uterine nuclear estrogen receptor: dependence on RNA and protein synthesis.

Altered enolase in aged Turbatrix aceti results from conformational changes in the enzyme.

Oligosaccharide motion in erythrocyte membranes investigated by picosecond fluorescence polarization and microsecond dichroism of an optical probe.

Fast axonal transport in the presence of high Ca2+: evidence that microtubules are not required.

Metabolism of native and of lactosylated human low density lipoprotein: evidence for two pathways for catabolism of exogenous proteins in rat hepatocytes.

Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents.

Spontaneous production of human interferon.

Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.

Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes.

Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.

Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes.

Sendai virus utilizes specific sialyloligosaccharides as host cell receptor determinants.

Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen.

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(R)-mevalonate excretion in human and rat urines.

beta-Endorphin: characteristics of binding sites in rabbit spinal cord.

Structure of endogenous murine leukemia virus DNA in mouse genomes.

Identification of ecotropic proviral sequences in inbred mouse strains with a cloned subgenomic DNA fragment.

Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein.

Characterization of a receptor-like protein for 1,25-dihydroxyvitamin D3 in rat skin.

Comparison of two delta-crystallin genes in the chicken.

Calcium-dependent hormonal regulation of amino acid transport and cyclic AMP accumulation in rat hepatocyte monolayer cultures.

Effects of combined glutamine and serum deprivation on glucose control of hexose transport in mammalian fibroblast cultures.

Platelet-derived growth factor stimulates low density lipoprotein receptor activity in cultured human fibroblasts.

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Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas.

Site specificity of mutations arising in dysgenic hybrids of Drosophila melanogaster.

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Parathyroid hormone alters collagen synthesis and procollagen mRNA levels in fetal rat calvaria.

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In vitro synthesis of 1 alpha,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol by isolated calvarial cells.

Immunological identification of the human erythrocyte glucose transporter.

Subunit neighbor interactions in enzyme kinetics: half-of-the-sites reactivity in a dimer.

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Exons encode functional and structural units of chicken lysozyme.

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Calcium-regulated phosphorylation in synaptosomal cytosol: dependence on calmodulin.

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Transcription units of chicken ovalbumin gene observed after injection of cloned complete genes into Xenopus oocyte nuclei.

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Association of ribosomal genes in the fibrillar center of the nucleolus: a factor influencing translocation and nondisjunction in the human meiotic oocyte.

Rate of spontaneous mutation at human loci encoding protein structure.

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Molecular cloning of a human histocompatibility antigen cDNA fragment.

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Nucleotide sequence of the thrA gene of Escherichia coli.

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Differential efficacies of human type I and type II interferons as antiviral and antiproliferative agents.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rubin, B. Y. Gupta, S. L.
Abstract	Treatment of human fibroblast FS-4 cultures with human type II interferon preparations induced the synthesis of at least four proteins that were similar in size to four of the five proteins induced by type I interferons (Mr 120,000, 88,000, 67,000, and 56,000). However, the Mr 67,000 and 56,000 proteins were induced more strongly by type II than by type I interferon, and a counterpart of a Mr 80,000 protein induced by type I interferons was not noticeably induced by type II interferon preparations. We therefore compared type I and type II interferons for relative antiviral activities against different viruses (vesicular stomatitis, encephalomyocarditis, and vaccinia viruses and reovirus) and for cell growth-inhibitory activities on various cell types. The replication of vesicular stomatitis and encephalomyocarditis viruses was inhibited more strongly by type I interferon, whereas reovirus and vaccinia virus showed greater sensitivity to type II interferon preparations. This indicates that viruses may differ in their sensitivity to human type I and type II interferons and that the antiviral mechanisms induced by type I and type II interferons may have significant differences. The type I and type II interferons may have significant differences. The type I and type II interferons may also differ in their efficacies as antiproliferative agents. Type II interferon preparations at 2.5 units/ml inhibited the incorporatin of [3H]thymidine to a greater extent than did type I interferon at 400 units/ml. (For both type I and type II interferons, the unit of interferon activity was defined as the concentration that decreased the yield of vesicular stomatitis virus by 50% in FS-4 cultures.) Furthermore, whereas type II interferon preparations had a reversible cytostatic effect on normal human fibroblasts at 10 units/ml, the transformed cells tested (HeLa, osteosarcoma, U-amnion) showed extensive cell death, thus indicating that it may have a cytocidal effect on certain tumor cells. It appears that human type II interferon (or a factor present in these preparations) may be a potent antitumor agent.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	77
Language	English
Publisher	National Academy of Sciences
Publisher Date	1980-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Division Drug Effects Interferons Pharmacology Virus Replication Cell Transformation, Neoplastic Pathology Cells, Cultured Fibroblasts Leukocytes Molecular Weight Protein Biosynthesis Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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