NDLI: Abnormal processing of multiple proteins in Alzheimer disease.

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Improved predictions of secondary structures for RNA.

Transcriptional regulation and DNA methylation of nuclear genes for photosynthesis in nongreen plant cells.

Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 86 Issue: 20)

Traveling waves of in vitro evolving RNA.

Presence of maternal antibodies to human immunodeficiency virus 1 envelope glycoprotein gp120 epitopes correlates with the uninfected status of children born to seropositive mothers.

Transient projection from the superior temporal sulcus to area 17 in the newborn macaque monkey.

Discrimination of heterogenous mRNAs encoding strychnine-sensitive glycine receptors in Xenopus oocytes by antisense oligonucleotides.

Mutation of the proteolipid protein gene PLP in a human X chromosome-linked myelin disorder.

Histamine directly gates a chloride channel in lobster olfactory receptor neurons.

N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex.

Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.

Isolation of the alpha subunits of GTP-binding regulatory proteins by affinity chromatography with immobilized beta gamma subunits.

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.

Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA.

Pancreatic islet-specific T-cell clones from nonobese diabetic mice.

Evolution of immunoglobulin genes: VH families in the amphibian Xenopus.

Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.

Agkistrodon piscivorus piscivorus platelet aggregation inhibitor: a potent inhibitor of platelet activation.

Effect of multiple interferon gamma injections on the disposal of Mycobacterium leprae.

Translocation of synapsin I in response to depolarization of isolated nerve terminals.

A simple chemosensory response in Drosophila and the isolation of acj mutants in which it is affected.

ATP-sensitive K+ channels in a plasma membrane H+-ATPase mutant of the yeast Saccharomyces cerevisiae.

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.

Two high-affinity interleukin 1 receptors represent separate gene products.

Evidence for different interleukin 1 receptors in murine B- and T-cell lines.

v-maf, a viral oncogene that encodes a 'leucine zipper' motif.

Avian proto-myc genes promoted by defective or nondefective retroviruses are single-hit transforming genes in primary cells.

Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone.

cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.

Hydroxyl radical 'footprinting' of RNA: application to pre-mRNA splicing complexes.

Another version of the human insulin receptor kinase domain: expression, purification, and characterization.

Increases in Na+,K+-ATPase activity of erythrocytes and skeletal muscle after chronic ethanol consumption: evidence for reduced efficiency of the enzyme.

Structural changes in bacteriorhodopsin during proton translocation revealed by neutron diffraction.

Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes.

Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable.

Mouse NIH 3T3 cells expressing human colony-stimulating factor 1 (CSF-1) receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor.

Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy.

Transmembrane domain of the envelope gene of a polycythemia-inducing retrovirus determines erythropoietin-independent growth.

alar4, a constitutive mutant of the A system for amino acid transport, has increased abundance of the Na+,K+-ATPase and mRNA for alpha 1 subunit of this enzyme.

Construction of a recombinant human parvovirus B19: adeno-associated virus 2 (AAV) DNA inverted terminal repeats are functional in an AAV-B19 hybrid virus.

Inhibition of inactivation of single sodium channels by a site-directed antibody.

Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform.

Drosophila NK-homeobox genes.

Individuals with IgA deficiency and common variable immunodeficiency share polymorphisms of major histocompatibility complex class III genes.

Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells.

Convergence and divergence of neurotransmitter action in human cerebral cortex.

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

Biochemical and crystallographic characterization of a complex of c-Ha-ras p21 and caged GTP with flash photolysis.

Lon-dependent regulation of the DNA binding protein HU in Escherichia coli.

Cell-surface expression and purification of human CD4 produced in baculovirus-infected insect cells.

Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.

Sensory rhodopsins I and II modulate a methylation/demethylation system in Halobacterium halobium phototaxis.

Heterologous expression of a wheat high molecular weight glutenin gene in Escherichia coli.

Differential regulation of two distinct glucose transporter species expressed in 3T3-L1 adipocytes: effect of chronic insulin and tolbutamide treatment.

Yeast TATA-box transcription factor gene.

Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues.

A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaK.

Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans.

Regulation of a bifunctional mRNA results in synthesis of secreted and nuclear probasin.

A lectin gene encodes the alpha-amylase inhibitor of the common bean.

Negative control of plasmid R6K replication: possible role of intermolecular coupling of replication origins.

Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coli.

The adenylyl cyclase gene from Schizosaccharomyces pombe.

Secretion and cell surface expression of IgG1 are impaired in human B lymphoblasts that lack HLA-A, -B, and -C antigens. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 86 Issue: 20)

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode.

Ultrasound-enhanced polymer degradation and release of incorporated substances.

Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations.

Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics.

Developmentally regulated gene from Leishmania encodes a putative membrane transport protein.

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Protein-electroblotting and -microsequencing strategies in generating protein data bases from two-dimensional gels.

Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin.

Monte Carlo description of oligoelectrolyte properties of DNA oligomers: range of the end effect and the approach of molecular and thermodynamic properties to the polyelectrolyte limits.

Myosin light chain enhancer activates muscle-specific, developmentally regulated gene expression in transgenic mice.

3' noncoding region of phosphoenolpyruvate carboxykinase mRNA contains a glucocorticoid-responsive mRNA-stabilizing element.

Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells.

c-ets-2 protooncogene has mitogenic and oncogenic activity.

Clostridial glycine reductase: protein C, the acetyl group acceptor, catalyzes the arsenate-dependent decomposition of acetyl phosphate.

Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase.

Associative memory neural network with low temporal spiking rates.

On the ion selectivity in Ca-binding proteins: the cyclo(-L-Pro-Gly-)3 peptide as a model.

Site-specific mutations alter in vitro factor binding and change promoter expression pattern in transgenic plants.

Systemic accumulation of specific mRNAs in response to wounding in poplar trees.

Extracellular ATP is a mitogen for 3T3, 3T6, and A431 cells and acts synergistically with other growth factors.

Internal cell manipulation using infrared laser traps.

Familiar neighbors enhance breeding success in birds.

Molecular definition of bovine argininosuccinate synthetase deficiency.

Molecular complementation of a genetic marker in Dictyostelium using a genomic DNA library.

Ability to perceive androstenone can be acquired by ostensibly anosmic people.

Glycine tRNA mutants with normal anticodon loop size cause -1 frameshifting.

Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain.

Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.

Abnormal processing of multiple proteins in Alzheimer disease.

Directly repeated sequences associated with pathogenic mitochondrial DNA deletions.

Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.

Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses.

Synaptic plasticity in rat hippocampal slice cultures: local 'Hebbian' conjunction of pre- and postsynaptic stimulation leads to distributed synaptic enhancement.

Isolation and expression of the eclosion hormone gene from the tobacco hornworm, Manduca sexta.

Molecular cloning and sequencing of a cDNA of rat dopa decarboxylase: partial amino acid homologies with other enzymes synthesizing catecholamines.

Hypothesis: microtubules, a key to Alzheimer disease.

Primary structure of two neuropeptide hormones with adipokinetic and hypotrehalosemic activity isolated from the corpora cardiaca of horse flies (Diptera).

Searching for pharmacophores in large coordinate data bases and its use in drug design.

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Specific photoaffinity labeling of two plasma membrane polypeptides with an azido auxin.

Phytochrome induces changes in the immunodetectable level of a wall peroxidase that precede growth changes in maize seedlings.

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Abnormal processing of multiple proteins in Alzheimer disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rubinstein, L. J. Zhang, H. Sternberger, N. H. Herman, M. M. Binder, L. I. Sternberger, L. A.
Description	Author Affiliation: Zhang H ( Department of Neurology, University of Maryland School of Medicine, Baltimore 21201.);
Abstract	Cerebrovascular amyloid is the main constituent of the perivascular and neuritic plaques typical of Alzheimer disease, whereas neurofilaments and microtubule-associated tau protein have been considered primary contributors to the formation of the characteristic Alzheimer tangles. Plaques and tangles and their constituents have at times been ascribed a role in pathogenesis of the disease. Normally, neurofilaments become phosphorylated only upon axonal entry. In many neurologic disorders, neurofilament phosphorylation, as detected by any of the available monoclonal antibodies (mAbs) to neurofilament phosphorylated epitopes is shifted from an axonal to a cell-body location. An exception is provided by Alzheimer disease, where tangles (which are neuronal cell-body-derived structures) exhibit only one phosphorylated epitope. However, the very presence of neurofilaments in tangles and plaques has been questioned because of a reported cross-reaction of mAbs to phosphorylated neurofilaments with tau protein. On reinvestigating this cross-reactivity we found that four of five mAbs to phosphorylated neurofilaments and four of five mAbs to nonphosphorylated neurofilaments failed to react with tau protein. A fifth mAb (07-5) to phosphorylated neurofilament cross-reacted with partially denatured tau protein at an affinity 1/1700th of that for denatured neurofilaments; nondenatured tau protein in tissue sections did not cross-react. A fifth mAb (02-40) to nonphosphorylated neurofilament also cross-reacted weakly. In Alzheimer disease normal-appearing axons were revealed with all the mAbs to phosphorylated neurofilaments, but tangles were revealed with only one of them (mAb 07-5). mAb to tau protein did not stain or did so indistinctly. Four of five mAbs to nonphosphorylated neurofilaments failed to reveal axons. Upon dephosphorylation of tissue, staining by mAbs to phosphorylated neurofilaments disappeared, and axons were revealed with the mAb to tau protein and all mAbs to the nonphosphorylated neurofilaments. Tangles became stained with tau mAb and one mAb to the nonphosphorylated neurofilaments (mAb 10-1). Quantitative evaluation of immunocytochemical staining intensities and immunoblot cross-reactivity showed that neurofilaments are, indeed, constituents of tangles--apparently exceeding the concentration of tau protein 17-fold. Contribution of both conformation and primary structure to IgG specificity may explain the lack of any cross-reaction of mAbs to neurofilaments with tau protein in intact tissue and the appearance of cross-reaction in immunoblots where conformation specificity may be largely lost. The present data extend earlier findings of abnormal processing of neurofilaments and tau protein in Alzheimer disease and, together with reported abnormal processing of cerebrovascular amyloid beta-protein, suggest that inhibition of the processing of multiple proteins is basic to the pathogenesis of Alzheimer disease, whereas formation of plaques and tangles could be merely the most striking histologic result.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alzheimer Disease Metabolism Brain Nerve Tissue Proteins Genetics Aging Pathology Growth & Development Phosphorylation Protein Processing, Post-Translational Reference Values Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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