NDLI: Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.

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Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.

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Specific photoaffinity labeling of two plasma membrane polypeptides with an azido auxin.

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Interleukin 6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Z. Y. Kishimoto, T. Raynal, M. C. Mayer, L. Chen-kiang, S. Hirano, T.
Description	Author Affiliation: Raynal MC ( Brookdale Center for Molecular Biology, New York, NY 10029.);
Abstract	The molecular mechanism by which interleukin 6 (IL-6) induces terminal differentiation of B cells was investigated in a subpopulation of the clonal human B-lymphoblastoid cell line CESS selected for high density of cell surface IgG1. Induction of CESS cells with IL-6 resulted in a 15-fold preferential accumulation of secreted-specific gamma 1 (gamma 1s) mRNA but not of the alternatively processed membrane-specific gamma 1 (gamma 1m) mRNA. Similarly, microseconds mRNA but not the microns mRNA of the nonproductively rearranged mu heavy-chain allele was also increased. Accompanying the differential accumulation of gamma 1s mRNA was a 4.5-fold increase in lambda light-chain mRNA, leading to secretion of IgG1. Analyses of transcription in isolated nuclei demonstrated that transcriptional activation was the primary mechanism for quantitative increase of immunoglobulin mRNAs (5.5-fold for gamma 1 and mu and at least 2-fold for lambda). Since polymerase loading is diminished by 75% before reaching the downstream gamma 1m polyadenylylation site in CESS cells, irrespective of IL-6 induction, transcriptional pausing/termination appears intrinsic and contributes to the selection of gamma 1s and gamma 1m polyadenylylation sites in activated B cells. Furthermore, differential mRNA stabilization is likely to contribute to the alteration of the gamma 1s/gamma 1m mRNA ratio at IL-6 induction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation Genes, Immunoglobulin Drug Effects Immunoglobulin G Biosynthesis Interleukin-6 Pharmacology RNA, Messenger Transcription, Genetic B-Lymphocytes Immunology Blotting, Northern Cell Line Genetics Molecular Sequence Data Oligonucleotide Probes Chemical Synthesis Plasmids Recombinant Proteins Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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