NDLI: Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease.

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Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease.

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Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dobkins, K. R. Saitoh, T.
Abstract	We have established in vitro conditions under which we can reliably measure kinase activity in normal postmortem human brain. Using these conditions, we detected in the brains of patients with Alzheimer disease a 2-fold increase in the level of Mr 60,000 protein phosphorylation compared to age-matched controls. The Mr 60,000 protein phosphorylation was found exclusively in the cytosol fraction. No differences were detected between phosphoproteins in 100,000 X g pellet fractions from brains of Alzheimer disease patients and from age-matched controls. Postmortem time up to 17 hr does not seem to affect the phosphorylation level of the Mr 60,000 protein. Younger Alzheimer disease patients had more prominent changes in the elevation of the Mr 60,000 protein phosphorylation level than older patients, although in the control patient, age did not affect the phosphorylation level of the Mr 60,000 protein. We conclude that in the brain cytosol of Alzheimer disease there may be an abnormality in either the degree of Mr 60,000 protein phosphorylation or in the Mr 60,000 protein concentration.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	83
Language	English
Publisher	National Academy of Sciences
Publisher Date	1986-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alzheimer Disease Metabolism Brain Nerve Tissue Proteins Phosphoproteins Autopsy Cytosol Molecular Weight Phosphorylation Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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