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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mezey, E. Hoffman, B. J. Usdin, T. B. Chen, C. Brownstein, M. J. |
| Description | Author Affiliation: Usdin TB ( Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.); |
| Abstract | A cDNA encoding the dopamine transporter from bovine brain substantia nigra was identified on the basis of its structural homology to other, recently cloned, neurotransmitter transporters. The sequence of the 693-amino acid protein is quite similar to those of the rat gamma-aminobutyric acid, human norepinephrine, and rat serotonin transporters. Dopamine transporter mRNA was detected by in situ hybridization in the substantia nigra but not in the locus coeruleus, raphe, caudate, or other brain areas. [3H]Dopamine accumulation in tissue culture cells transfected with the cDNA was inhibited by amphetamine, cocaine, and specific inhibitors of dopamine transport, including GBR12909. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 88 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1991-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carrier Proteins Genetics Cocaine Pharmacology Dopamine Metabolism Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Substantia Nigra Physiology Amino Acid Sequence Animals Antisense Elements (Genetics) Drug Effects Cell Line Cloning, Molecular Dopamine Antagonists Dopamine Plasma Membrane Transport Proteins Gene Library Kinetics Molecular Sequence Data Nucleic Acid Hybridization Piperazines RNA Isolation & Purification RNA Probes Sequence Homology, Nucleic Acid Transfection Tyrosine 3-Monooxygenase Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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