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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xia, Y. Espinosa, R. Tsan, J. T. Le Beau, M. M. Yang, C. Y. Brown, L. Baer, R. J. Siciliano, M. J. |
| Description | Author Affiliation: Xia Y ( Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.); |
| Abstract | Tumor-specific alteration of the TAL1 gene occurs in almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL). We now report the identification of TAL2, a distinct gene that was isolated on the basis of its sequence homology with TAL1. The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL. As a consequence of t(7;9)(q34;q32), TAL2 is juxtaposed with sequences from the T-cell receptor beta-chain gene on chromosome 7. TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). The TAL2 gene product includes a helix-loop-helix protein dimerization and DNA binding domain that is especially homologous to those encoded by the TAL1 and LYL1 protooncogenes. Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 88 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1991-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 9 DNA-Binding Proteins Genetics Leukemia, T-Cell Leukemia-Lymphoma, Adult T-Cell Neoplasm Proteins Proto-Oncogenes Translocation, Genetic Amino Acid Sequence Animals Basic Helix-Loop-Helix Transcription Factors DNA, Neoplasm Isolation & Purification Gene Expression Regulation, Neoplastic Genetic Linkage Mice Molecular Sequence Data Oligodeoxyribonucleotides Open Reading Frames Polymerase Chain Reaction Restriction Mapping Sequence Homology, Nucleic Acid Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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