NDLI: Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

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Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

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Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ramamoorthy, S. Bauman, A. L. Moore, K. R. Han, H. Chang, A. S. Ganapathy, V. Yang-feng, T. Blakely, R. D.
Description	Author Affiliation: Ramamoorthy S ( Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.);
Abstract	A Na(+)- and Cl(-)-coupled serotonin (5-hydroxytryptamine, 5HT) transporter is expressed on human neuronal, platelet, placental, and pulmonary membranes. The brain 5HT transporter appears to be a principal site of action of therapeutic antidepressants and may mediate behavioral and/or toxic effects of cocaine and amphetamines. Oligonucleotides derived from consensus transporter sequences were used to identify human placental cDNAs highly related to the rat brain 5HT carrier. Transfection of one of these cDNAs into HeLa cells yields a high-affinity (Km = 463 nM), Na(+)- and Cl(-)-dependent 5HT transport activity which can be blocked by selective 5HT transport inhibitors, including paroxetine, fluoxetine, and imipramine, and which is antagonized by cocaine and amphetamine. Sequence analysis reveals a 630-amino acid open reading frame bearing 92% identity to the cloned rat brain 5HT transporter, with identical predicted topological features and conserved sites for posttranslational modifications. Unlike the rodent, where a single mRNA appears to encode 5HT transporters, multiple hybridizing RNAs are observed in human placenta and lung. Somatic cell hybrid and in situ hybridization studies are consistent, however, with a single gene encoding the human 5HT transporter, localized to chromosome 17q11.1-17q12.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antidepressive Agents Pharmacology Carrier Proteins Genetics Cocaine Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins Amino Acid Sequence Binding, Competitive Blood Platelets Metabolism Drug Effects Cell Line HeLa Cells Kinetics Lung Molecular Sequence Data Neurons Oligodeoxyribonucleotides Placenta Physiology Poly A Isolation & Purification Polymerase Chain Reaction Pregnancy RNA RNA, Messenger Serotonin Serotonin Plasma Membrane Transport Proteins Sodium Transfection Trophoblasts Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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