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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | O'neill, S. Mendelsohn, M. E. Zhu, Y. |
| Description | Author Affiliation: Mendelsohn ME ( Department of Medicine, Brigham and Women's Hospital, Boston, MA.); |
| Abstract | Thrombin plays a critical role in platelet activation, hemostasis, and thrombosis. Cellular activation by thrombin leads to the phosphorylation of multiple proteins, most of which are unidentified. We have characterized several 29-kDa proteins that are rapidly phosphorylated following exposure of intact human platelets to thrombin. A murine monoclonal antibody raised to an unidentified estrogen receptor-related 29-kDa protein selectively recognized these proteins as well as a more basic, unphosphorylated 27-kDa protein. Cellular activation by thrombin led to a marked shift in the proportion of protein from the 27-kDa unphosphorylated form to the 29-kDa phosphoprotein species. Using this antibody, we isolated and sequenced a human cDNA clone encoding a protein that was identical to the mammalian 27-kDa heat shock protein (HSP27), a protein of uncertain function that is known to be phosphorylated to several forms and to be transcriptionally induced by estrogen. The 29-kDa proteins were confirmed to be phosphorylated forms of HSP27 by immunoprecipitation studies. Thus, the 'estrogen receptor-related protein' is HSP27, and the three major 29-kDa proteins phosphorylated in thrombin-activated platelets are forms of HSP27. These data suggest a role for HSP27 in the signal transduction events of platelet activation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 24 |
| Volume Number | 88 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1991-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Blood Platelets Physiology Heat-Shock Proteins Blood Receptors, Estrogen Metabolism Thrombin Pharmacology Amino Acid Sequence Autoradiography Drug Effects DNA Genetics Isolation & Purification DNA, Recombinant Electrophoresis, Gel, Two-Dimensional Gene Library Immunoblotting In Vitro Techniques Molecular Sequence Data Molecular Weight Phosphorus Radioisotopes Phosphorylation Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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