NDLI: Emergence of the keratinocyte growth factor multigene family during the great ape radiation.

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Emergence of the keratinocyte growth factor multigene family during the great ape radiation.

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Emergence of the keratinocyte growth factor multigene family during the great ape radiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seuanez, H. N. Rubin, J. S. Pech, M. Aaronson, S. A. Kelley, M. J. O'brien, S. J.
Description	Author Affiliation: Kelley MJ ( Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.);
Abstract	The structural gene for human keratinocyte growth factor (KGF), a member of the fibroblast growth factor family, consists of three coding exons and two introns typical of other fibroblast growth factor loci. A portion of the KGF gene, located on chromosome 15, is amplified to approximately 16 copies in the human genome, and these highly related copies (which consist of exon 2, exon 3, the intron between them, and a 3' noncoding segment of the KGF transcript) are dispersed to multiple human chromosomes. The KGF-like sequences are transcriptionally active, differentially regulated in various tissues, and composed of three distinct classes of coding sequences that are 5% divergent from each other and from the authentic KGF sequence. Multiple copies of KGF-like genes were also discovered in the genomic DNAs of chimpanzee and gorilla but were not found in lesser apes (gibbon), Old World monkeys (African green monkey and macaques), mice, or chickens. The pattern of evolutionary occurrence suggests that a primordial KGF gene was amplified and chromosomally dispersed subsequent to the divergence of orangutan from African apes but before the trichotomous divergence of human, chimpanzee, and gorilla 5-8 million years ago. The appearance of a transcriptionally active and chromosomally dispersed multigene KGF family may have implications in the evolution of the great apes and humans.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Biological Evolution Fibroblast Growth Factors Growth Substances Genetics Multigene Family Primates Animals Cercopithecus Aethiops Chromosome Mapping Cloning, Molecular DNA Isolation & Purification Fibroblast Growth Factor 10 Fibroblast Growth Factor 7 Gorilla Gorilla Hominidae Macaca Mulatta Molecular Sequence Data Oligodeoxyribonucleotides Pan Troglodytes Polymerase Chain Reaction Pongo Pygmaeus Restriction Mapping Sequence Homology, Nucleic Acid Comparative Study Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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