NDLI: Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1992 Volume: 89 Issue: 24

Year: 1992 Volume: 89 Issue: 23

Year: 1992 Volume: 89 Issue: 22

Year: 1992 Volume: 89 Issue: 21

Year: 1992 Volume: 89 Issue: 20

Year: 1992 Volume: 89 Issue: 19

Transition metals in legume root nodules: iron-dependent free radical production increases during nodule senescence.

Puzzling questions about excited superdeformed rotational bands of atomic nuclei are answered by the two-revolving-cluster model.

Oldest fossil flowers of hamamelidaceous affinity, from the Late Cretaceous of New Jersey.

Contrasting leaf phenotypes control seasonal variation in water loss in a tropical forest shrub.

Solution of the discrete Plateau problem.

Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.

Inositol polyphosphate receptor and clathrin assembly protein AP-2 are related proteins that form potassium-selective ion channels in planar lipid bilayers.

Transduction of primary human hepatocytes with amphotropic and xenotropic retroviral vectors.

A point mutation in the MyoD basic domain imparts c-Myc-like properties.

Retinoid X receptor RXR alpha binds to and trans-activates the hepatitis B virus enhancer.

Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences.

Simian virus 40 minichromosomes as targets for retroviral integration in vivo.

Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.

[D-Ala2]deltorphin I binding and pharmacological evidence for a special subtype of delta opioid receptor on human and invertebrate immune cells.

Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

On the origin of the enthalpy and entropy convergence temperatures in protein folding.

Specific modulation of dopamine expression in neuronal hybrid cells by primary cells from different brain regions.

Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family.

Leukotriene A4 hydrolase: abrogation of the peptidase activity by mutation of glutamic acid-296.

Activation of a D2 receptor increases electrical coupling between retinal horizontal cells by inhibiting dopamine release.

Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II.

Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred.

In vitro selection of an RNA epitope immunologically cross-reactive with a peptide.

Major histocompatibility complex determinants select T-cell receptor alpha chain variable region dominance in a peptide-specific response.

GreA protein: a transcription elongation factor from Escherichia coli.

Spatial pattern of receptor expression in the olfactory epithelium.

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.

Cis-acting, orientation-dependent, positive control system activates pheromone-inducible conjugation functions at distances greater than 10 kilobases upstream from its target in Enterococcus faecalis.

Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction.

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.

D1-dopamine receptors activate c-fos expression in the fetal suprachiasmatic nuclei.

Higher plant Ca(2+)-ATPase: primary structure and regulation of mRNA abundance by salt.

Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle.

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina.

CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.

Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro.

Expression patterns of gamma-aminobutyric acid type A receptor subunit mRNAs in primary cultures of granule neurons and astrocytes from neonatal rat cerebella.

A bifunctional enzyme (delta 1-pyrroline-5-carboxylate synthetase) catalyzes the first two steps in proline biosynthesis in plants.

Molecular cloning and characterization of additional factors that bind to the interferon-alpha/beta response element B of the murine (2'-5')oligoadenylate synthetase ME-12 gene.

Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.

Early regional specification for a molecular neuronal phenotype in the rat neocortex.

An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene.

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

Bacterial ADP-ribosyltransferase with a substrate specificity of the rho protein disassembles the Golgi apparatus in Vero cells and mimics the action of brefeldin A.

Centromere DNA mutations induce a mitotic delay in Saccharomyces cerevisiae.

Identification of a second insulin-like growth factor in a fish species.

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

Monomers and dimers of the RepA protein in plasmid pSC101 replication: domains in RepA.

Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells.

Defective guanyl nucleotide-binding protein beta gamma subunits in a forskolin-resistant mutant of the Y1 adrenocortical cell line.

Emr, an Escherichia coli locus for multidrug resistance.

Antifreeze protein modulates cell survival during cryopreservation: mediation through influence on ice crystal growth.

Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts.

Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes.

Proposed acquisition of an animal protein domain by bacteria.

A strategy for making synthetic peptide vaccines.

Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

Another perspective on the visual motion aftereffect.

Protein tertiary structure recognition using optimized Hamiltonians with local interactions.

Model studies directed toward the boron neutron-capture therapy of cancer: boron delivery to murine tumors with liposomes.

Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon.

In the presence of dexamethasone, gamma interferon induces rat oligodendrocytes to express major histocompatibility complex class II molecules.

Glucocorticoid-induced formation of tight junctions in mouse mammary epithelial cells in vitro.

Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium.

Cell-specific expression of a Clara cell secretory protein-human growth hormone gene in the bronchiolar epithelium of transgenic mice.

Precursor structure, expression, and tissue distribution of human guanylin.

Protein stitchery: design of a protein for selective binding to a specific DNA sequence.

Molecular cloning of a candidate chicken prion protein.

Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses.

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1.

Accurate and rapid detection of heterozygous carriers of a deletion by combined polymerase chain reaction and high-performance liquid chromatography.

Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis.

Agroinfection as an alternative to insects for infecting plants with beet western yellows luteovirus.

Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure.

Coat protein gene duplication in a filamentous RNA virus of plants.

Translocation of apolipoprotein B across the endoplasmic reticulum is blocked in a nonhepatic cell line.

Uncoupling gene activity from chromatin structure: promoter mutations can inactivate transcription of the yeast HSP82 gene without eliminating nucleosome-free regions.

In vitro differentiation of embryonic stem cells into lymphocyte precursors able to generate T and B lymphocytes in vivo.

Characterization of Plasmodium falciparum sporozoite surface protein 2.

Anion sensitivity and spectral tuning of cone visual pigments in situ.

Interactions between natural polyamines and tRNA: an 15N NMR analysis.

Phagocytosis of liposomes by human platelets.

Efficient mass transformation of Tetrahymena thermophila by electroporation of conjugants.

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

Combination of H-box [CCTACC(N)7CT] and G-box (CACGTG) cis elements is necessary for feed-forward stimulation of a chalcone synthase promoter by the phenylpropanoid-pathway intermediate p-coumaric acid.

Single-stranded nucleic acid helical secondary structure stabilized by ionic bonds: d(A(+)-G)10.

'Enzymogenesis': classical liver alcohol dehydrogenase origin from the glutathione-dependent formaldehyde dehydrogenase line.

Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.

Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase.

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

Differential interaction of ADP-ribosylation factors 1, 3, and 5 with rat brain Golgi membranes.

Regulation of thyroid hormone receptor-mediated transcription by a cytosol protein.

A sarcomeric alpha-actinin truncated at the carboxyl end induces the breakdown of stress fibers in PtK2 cells and the formation of nemaline-like bodies and breakdown of myofibrils in myotubes.

Emergence of the keratinocyte growth factor multigene family during the great ape radiation.

Characterization and mutagenesis of the gene encoding the A49 subunit of RNA polymerase A in Saccharomyces cerevisiae.

Functional expression of zeaxanthin glucosyltransferase from Erwinia herbicola and a proposed uridine diphosphate binding site.

Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.

Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.

Year: 1992 Volume: 89 Issue: 18

Year: 1992 Volume: 89 Issue: 17

Year: 1992 Volume: 89 Issue: 16

Year: 1992 Volume: 89 Issue: 15

Year: 1992 Volume: 89 Issue: 14

Year: 1992 Volume: 89 Issue: 13

Year: 1992 Volume: 89 Issue: 12

Year: 1992 Volume: 89 Issue: 11

Year: 1992 Volume: 89 Issue: 10

Year: 1992 Volume: 89 Issue: 9

Year: 1992 Volume: 89 Issue: 8

Year: 1992 Volume: 89 Issue: 7

Year: 1992 Volume: 89 Issue: 6

Year: 1992 Volume: 89 Issue: 5

Year: 1992 Volume: 89 Issue: 4

Year: 1992 Volume: 89 Issue: 3

Year: 1992 Volume: 89 Issue: 2

Year: 1992 Volume: 89 Issue: 1

On the nature of global classification.

Theory of hydrophobicity: transient cavities in molecular liquids.

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tortora, G. Aldinucci, D. Zagonel, V. Cho-chung, Y. S. Gattei, V. Budillon, A. Pinto, A.
Description	Author Affiliation: Pinto A ( Leukemia Unit, Istituti Nazionali di Ricerca e Cura a Carattere Scientifico, Aviano, Italy.);
Abstract	The physiologic balance between the two regulatory subunit isoforms, RI and RII, of cAMP-dependent protein kinase is disrupted in cancer cells; growth arrest and differentiation of malignant cells can be achieved when the normal ratio of these intracellular signal transducers of cAMP is restored by the use of site-selective cAMP analogs. In this study we evaluated the effects of the site-selective cAMP analog 8-chloroadenosine 3',5'-cyclic monophosphate (8-Cl-cAMP) on clonogenic growth of blast progenitors from 15 patients with acute myeloblastic leukemia and 3 patients affected by advanced myelodysplastic syndrome. Leukemic blast progenitors undergo terminal divisions, giving rise to colonies in methylcellulose. The self-renewal capacity of blast progenitors is conversely reflected in a secondary methylcellulose assay after exponential growth of clonogenic cells in suspension cultures. In all the samples tested, 8-Cl-cAMP, at micromolar concentrations (0.1-50 microM), suppressed in a dose-dependent manner both primary colony formation in methylcellulose and the recovery of clonogenic cells from suspension culture. Strikingly, in the samples from the entire group of patients, 8-Cl-cAMP was more effective in inhibiting the self-renewing clonogenic cells than the terminally dividing blast cells (P = 0.005). In addition, in four out of six cases studied, 8-Cl-cAMP was able to induce a morphologic and/or immunophenotypic maturation of leukemic blasts. An evident reduction of RI levels in fresh leukemic cells after exposure to 8-Cl-cAMP was also detected. Our results showing that 8-Cl-cAMP is a powerful inhibitor of clonogenic growth of leukemic blast progenitors by primarily suppressing their self-renewal capacity indicate that this site-selective cAMP analog represents a promising biological agent for acute myeloblastic leukemia therapy in humans.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	8-Bromo Cyclic Adenosine Monophosphate Analogs & Derivatives Antineoplastic Agents Pharmacology Blast Crisis Pathology Cell Survival Drug Effects Leukemia, Myeloid, Acute Tumor Cells, Cultured Affinity Labels Metabolism Antigens, Surface Azides Culture Techniques Cyclic AMP Dose-Response Relationship, Drug Kinetics Receptors, Cyclic AMP Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in