NDLI: High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.

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High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.

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High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bowry, V. W. Stanley, K. K. Stocker, R.
Description	Author Affiliation: Bowry VW ( Biochemistry Group, Heart Research Institute, Sydney N.S.W., Australia.);
Abstract	Analysis of untreated fresh blood plasma from healthy, fasting donors revealed that high density lipoprotein (HDL) particles carry most (approximately 85%) of the detectable oxidized core lipoprotein lipids. Low density lipoprotein (LDL) lipids are relatively peroxide-free. In vitro the mild oxidation of gel-filtered plasma from fasting donors with a low, steady flux of aqueous peroxyl radicals initially caused preferential oxidation of HDL rather than LDL lipids until most ubiquinol-10 present in LDL was consumed. Thereafter, LDL core lipids were oxidized more rapidly. Isolated lipoproteins behaved similarly. Preferential accumulation of lipid hydroperoxides in HDL reflects the lack of antioxidants in most HDL particles compared to LDL, which contained 8-12 alpha-tocopherol and 0.5-1.0 ubiquinol-10 molecules per particle. Cholesteryl ester hydroperoxides (CEOOHs) in HDL and LDL were stable when added to fresh plasma at 37 degrees C for up to 20 hr. Transfer of CEOOHs from HDL to LDL was too slow to have influenced the in vitro plasma oxidation data. Incubation of mildly oxidized LDL and HDL with cultured hepatocytes afforded a linear removal of CEOOHs from LDL (40% loss over 1 hr), whereas a fast-then-slow biphasic removal was observed for HDL. Our data show that HDL is the principal vehicle for circulating plasma lipid hydroperoxides and suggest that HDL lipids may be more rapidly oxidized than those in LDL in vivo. The rapid hepatic clearance of CEOOHs in HDL could imply a possible beneficial role of HDL by attenuating the build-up of oxidized lipids in LDL.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fasting Blood Lipid Peroxides Lipoproteins, HDL Antioxidants Metabolism Carcinoma, Hepatocellular Chromatography, High Pressure Liquid Isolation & Purification Liver Neoplasms Luminescent Measurements Tumor Cells, Cultured Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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