NDLI: A region of group I introns that contains universally conserved residues but is not essential for self-splicing.

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A region of group I introns that contains universally conserved residues but is not essential for self-splicing.

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A region of group I introns that contains universally conserved residues but is not essential for self-splicing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fujimoto, D. N. Williams, K. P. Inoue, T.
Description	Author Affiliation: Williams KP ( Salk Institute for Biological Studies, La Jolla, CA 92037.);
Abstract	The catalytic core of the self-splicing group I intron RNAs is composed of six paired regions together with their connecting sequences; these are thought to form two elongated domains, with paired regions P5, P4, and P6 aligned along one axis and P8, P3, and P7 along the other. Most of the very highly conserved residues of the group I introns lie in or near P7, but two occur in L4, the internal loop connecting P4 and P5. It is generally believed that such bases are conserved because they are essential for splicing. Mutants were created in a member of each of the two major subclasses of group I introns, in which P5, L4, and the distal portion of P4 were deleted. Splicing activity was still detected in these mutants, albeit substantially weakened; splicing was accurate and occurred by the normal group I mechanism, with addition of a guanosine molecule to the intron. Thus the deleted region, containing two universally conserved bases, is not essential but facilitates splicing. Another reaction characteristic of group I introns, hydrolysis of the 3' splice site, was less severely affected by the deletions. The results are discussed in terms of the prevailing three-dimensional model for the core structure of the group I introns.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Introns RNA Splicing RNA, Messenger Genetics RNA Tetrahymena Thermophila Tetrahymena Animals Exons Molecular Sequence Data Nucleic Acid Conformation Chemistry RNA Precursors Isolation & Purification Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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