NDLI: Hepatitis B virus capsid particles are assembled from core-protein dimer precursors.

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Hepatitis B virus capsid particles are assembled from core-protein dimer precursors.

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On the nature of global classification.

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Hepatitis B virus capsid particles are assembled from core-protein dimer precursors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, S. Standring, D. N.
Description	Author Affiliation: Zhou S ( Hormone Research Institute, University of California, San Francisco 94143-0534.);
Abstract	Our studies on the assembly of hepatitis B virus capsids or core particles in Xenopus oocytes have demonstrated that unassembled p21.5 core proteins ('free p21.5') provide a pool of low-molecular-mass precursors for core-particle assembly. Here we have characterized this material. Free p21.5 sedimented through gradients of 3-25% sucrose (wt/vol) as a single protein species of approximately 40 kDa, corresponding to a p21.5 dimer. On nonreducing SDS/polyacrylamide gels, free p21.5 migrated as disulfide-linked p21.5 dimeric species of 35 and 37 kDa. Truncated core proteins lacking most or all of the 36-amino acid protamine region at the p21.5 carboxyl terminus were also found to behave as disulfide-linked dimers with appropriately reduced molecular masses. Our experiments failed to reveal monomeric core proteins or stable intermediates between dimers and capsids along the assembly pathway. We conclude that hepatitis B virus core particles are most likely assembled by aggregating 90 (or possibly 180) disulfide-linked p21.5 dimers. We discuss similarities between the assembly of hepatitis B virus capsids and simple T = 3 plant virus and bacteriophage structures.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Capsid Biosynthesis Hepatitis B Virus Metabolism Protein Precursors Viral Core Proteins Animals Isolation & Purification Centrifugation, Density Gradient Cysteine Electrophoresis, Polyacrylamide Gel Macromolecular Substances Molecular Weight Oocytes Plasmids RNA, Messenger Recombinant Proteins Sulfur Radioisotopes Xenopus Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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