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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Proudfoot, Julie M. Barden, Anne E. Loke, Wai Mun Croft, Kevin D. Puddey, Ian B. Mori, Trevor A. |
| Description | Country affiliation: Australia Author Affiliation: Proudfoot JM ( School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Perth WA 6847, Australia.) |
| Abstract | Enhanced oxidative stress is implicated in the development of atherosclerosis in humans and animal models. F(2)-isoprostanes are formed in vivo via free radical peroxidation of arachidonic acid, and their quantification has allowed assessment of oxidative stress in vivo. F(2)-isoprostanes associate with lipids, although their distribution in human plasma lipoproteins is unknown. Our aim was to determine the distribution and levels of F(2)-isoprostanes in lipoproteins isolated from human plasma by ultracentrifugation and fast protein liquid chromatography (FPLC). F(2)-isoprostanes were significantly higher in HDL compared with LDL or VLDL after isolation by ultracentrifugation or FPLC. Furthermore, HDL3 particles contained elevated levels of F(2)-isoprostanes compared with HDL2. Platelet activating factor acetylhydrolase (PAF-AH), which hydrolyses esterified F(2)-isoprostanes from phospholipids, was predominantly associated with LDL. Reduced F(2)-isoprostanes in LDL may be related to higher PAF-AH activity in LDL. Paraoxonase 1 (PON-1) activity was associated with HDL2 and may be a contributing factor to the lower F(2)-isoprostanes in HDL2 compared with HDL3. Further studies are required to establish the implications of these findings on HDL function. |
| File Format | HTM / HTML |
| ISSN | 00222275 |
| e-ISSN | 15397262 |
| DOI | 10.1194/jlr.M800607-JLR200 |
| Journal | The Journal of Lipid Research |
| Issue Number | 4 |
| Volume Number | 50 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2009-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry F2-isoprostanes Blood Lipoproteins, Hdl 1-alkyl-2-acetylglycerophosphocholine Esterase Amidines Pharmacology Arachidonic Acid Aryldialkylphosphatase Atherosclerosis Etiology Biological Transport, Active Carrier Proteins In Vitro Techniques Linoleic Acid Lipid Peroxides Lipoproteins Oxidants Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Endocrinology |
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