NDLI: BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element.

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BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element.

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BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martignetti, J. A. Brosius, J.
Description	Author Affiliation: Martignetti JA ( Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029.);
Abstract	We demonstrate that the BC200 RNA gene, which encodes a neural small cytoplasmic RNA, is a member of the most prodigious family of interspersed repetitive DNA and that its product represents an example of a primate tissue-specific RNA polymerase III transcript. The BC200 RNA gene is an early monomeric member and one of the few postulated transcriptionally active Alu sequences in this family of nearly half a million retropositionally amplified elements dispersed throughout the human genome. Furthermore, the isolation of two pseudogenes, BC200 beta and BC200 gamma, demonstrates the gene's transpositional ability. Interestingly, the BC200 beta pseudogene may have been generated by a conversion-like event after the human/chimpanzee divergence, resulting in an exchange of the left arm of a dimeric Alu element with the BC200 RNA coding sequence. Our data on conserved features of the active BC200 alpha gene suggest that its RNA product has been 'exapted' into a function of the primate brain and provides a selective advantage to the species.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Metabolism Conserved Sequence Genome, Human Hominidae Genetics Neurons RNA Polymerase III Animals Gene Conversion Gene Expression Genomic Library Molecular Sequence Data Oligodeoxyribonucleotides Pan Troglodytes Primates Pseudogenes Biosynthesis Restriction Mapping Sequence Homology, Nucleic Acid Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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