NDLI: Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases.

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Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases.

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Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Utani, A. Yamada, Y. Pan, Z. Q. Burbelo, P. D.
Description	Author Affiliation: Burbelo PD ( Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.);
Abstract	We have cloned a gene encoding a DNA-binding protein by Southwestern screening of a murine cDNA library with a double-stranded oligonucleotide containing the sequence from the bidirectional promoter of the alpha 1 and alpha 2 collagen IV genes. The middle portion of this 1131-amino acid protein has a region homologous to bacterial DNA ligases, and the more carboxyl portion contains several domains homologous to p40, p38, p37, and p36.5 subunits of activator 1 (A1, also called replication factor C), a human replication protein complex. Western blotting revealed that antiserum generated against part of the recombinant protein reacted specifically with the 145-kDa component of the purified human A1 complex, indicating that it is the murine counterpart of the A1 p145. Characterization of the DNA-binding activity of the recombinant fusion protein by gel mobility-shift assay revealed that it had a preference for a run of pyrimidines on one strand. Deletion analysis using recombinant proteins revealed that the DNA ligase-like domain was required for DNA-binding activity. The finding that the region required for the binding of murine A1 p145 to DNA has similarity to a domain found in DNA ligases suggests that this region may be utilized by both proteins in recognizing DNA.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacteria Enzymology DNA Ligases Genetics DNA-Binding Proteins Homeodomain Proteins Proto-Oncogene Proteins C-bcl-2 Repressor Proteins Saccharomyces Cerevisiae Proteins Amino Acid Sequence Animals Blotting, Western Cloning, Molecular Collagen Chemistry DNA Replication Embryo, Mammalian HeLa Cells Immune Sera Immunoblotting Macromolecular Substances Mice Minor Histocompatibility Antigens Molecular Sequence Data Oligodeoxyribonucleotides Promoter Regions, Genetic Replication Protein C Schizosaccharomyces Sequence Homology, Amino Acid Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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