NDLI: Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1993 Volume: 90 Issue: 24

The accessory bacteriochlorophyll: a real electron carrier in primary photosynthesis.

Primer-mediated in situ detection of the B-hordein gene cluster on barley chromosome 1H.

Equilibration during mantle melting: a fractal tree model.

Signal efficacy and the evolution of male dimorphism in the jumping spider, Maevia inclemens.

Distortion of area and dimension under quasiconformal mappings in the plane.

Microtubules and Src homology 3 domains stimulate the dynamin GTPase via its C-terminal domain.

Identification of a cytochrome P450 gene by reverse transcription--PCR using degenerate primers containing inosine.

Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.

V3 variability can influence the ability of an antibody to neutralize or enhance infection by diverse strains of human immunodeficiency virus type 1.

The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C' face of the human CD2 adhesion domain.

Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen.

Cys4057 of apolipoprotein(a) is essential for lipoprotein(a) assembly.

Functional kainate-selective glutamate receptors in cultured hippocampal neurons.

Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cells.

Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications.

A gene encoding a protein related to eukaryotic protein kinases from the filamentous heterocystous cyanobacterium Anabaena PCC 7120.

Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation.

Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.

Number of CpG islands and genes in human and mouse.

Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes.

In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2.

Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells.

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

Eukaryotic cytosolic chaperonin contains t-complex polypeptide 1 and seven related subunits.

Testosterone in egg yolks: an ornithologist's perspective.

Cellular signaling: new insights into the action of the plant growth hormone auxin.

Yolk is a source of maternal testosterone for developing birds.

Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system.

Structurally engineered cytochromes with unusual ligand-binding properties: expression of Saccharomyces cerevisiae Met-80-->Ala iso-1-cytochrome c.

Strings of contiguous modified pentanucleotides with increased DNA-binding affinity can be used for DNA sequencing by primer walking.

Transmembrane neural cell-adhesion molecule (NCAM), but not glycosyl-phosphatidylinositol-anchored NCAM, down-regulates secretion of matrix metalloproteinases.

Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63.

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.

Modulation of K+ channels in Vicia stomatal guard cells by peptide homologs to the auxin-binding protein C terminus.

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1.

Identification of human DNA topoisomerase I as a cofactor for activator-dependent transcription by RNA polymerase II.

The min K channel underlies the cardiac potassium current IKs and mediates species-specific responses to protein kinase C.

Translation of the human LINE-1 element, L1Hs.

Site-specific cleavage and joining of single-stranded DNA by VirD2 protein of Agrobacterium tumefaciens Ti plasmids: analogy to bacterial conjugation.

Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases.

Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex.

The relationship between synthetic and editing functions of the active site of an aminoacyl-tRNA synthetase.

Animals and fungi are each other's closest relatives: congruent evidence from multiple proteins.

BC200 RNA: a neural RNA polymerase III product encoded by a monomeric Alu element.

Transcriptional regulation of HLA-A and -B: differential binding of members of the Rel and IRF families of transcription factors.

Calcium permeability of the N-methyl-D-aspartate receptor channel in hippocampal neurons in culture.

Synaptic inhibition regulates associative interactions between afferents during the induction of long-term potentiation and depression.

DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.

Induction of erythroid-specific gene expression in lymphoid cells.

Localization of the colchicine-binding site of tubulin.

Evolution of nuclear ribosomal RNAs in kinetoplastid protozoa: perspectives on the age and origins of parasitism.

Osteoporosis induced in mice by overproduction of interleukin 4.

The mdm-2 gene is induced in response to UV light in a p53-dependent manner.

Rapid solution assays for retroviral integration reactions and their use in kinetic analyses of wild-type and mutant Rous sarcoma virus integrases.

Catalytic contribution of flap-substrate hydrogen bonds in 'HIV-1 protease' explored by chemical synthesis.

Val-->Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein.

Kinesin swivels to permit microtubule movement in any direction.

Evidence that facilitative glucose transporters may fold as beta-barrels.

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.

A fourth class of theta-replicating plasmids: the pAM beta 1 family from gram-positive bacteria.

Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.

Enhancer activity of light-responsive regulatory elements in the untranslated leader regions of cyanobacterial psbA genes.

Active immunity against the CD4 receptor by using an antibody antigenized with residues 41-55 of the first extracellular domain.

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Pulse mass measles vaccination across age cohorts.

Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria.

Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.

Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.

Multiple motifs regulate the B-cell-specific promoter of the B29 gene.

Mevalonate availability and cardiovascular functions.

A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection.

Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors.

IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer.

Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.

Long-range structural effects in a second-site revertant of a mutant dihydrofolate reductase.

The first step in vision occurs in femtoseconds: complete blue and red spectral studies.

A large cell-adhesive scatter factor secreted by human gastric carcinoma cells.

Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor.

Evolution and expression of a beta-like globin gene of the Australian marsupial Sminthopsis crassicaudata.

PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae.

Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.

Activation of human primary visual cortex during visual recall: a magnetic resonance imaging study.

Zinc modulation of a transient potassium current and histochemical localization of the metal in neurons of the suprachiasmatic nucleus.

The effect of sequences with high AU content on mRNA stability in tobacco.

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.

Metabolic correction and cross-correction of mucopolysaccharidosis type II (Hunter syndrome) by retroviral-mediated gene transfer and expression of human iduronate-2-sulfatase.

Acyclovir diphosphate dimyristoylglycerol: a phospholipid prodrug with activity against acyclovir-resistant herpes simplex virus.

The presequence of Euglena LHCPII, a cytoplasmically synthesized chloroplast protein, contains a functional endoplasmic reticulum-targeting domain.

Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A.

Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.

Fast events in protein folding initiated by nanosecond laser photolysis.

The minimal self-sufficient element in a murine G+C-rich promoter is a large element with imperfect dyad symmetry.

Genes in one megabase of the HLA class I region.

The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes.

Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.

Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.

Highly localized tracks of human immunodeficiency virus type 1 Nef in the nucleus of cells of a human CD4+ T-cell line.

A masculinizing effect on the auditory systems of human females having male co-twins.

Interleukin 6 inhibits mouse placental lactogen II but not mouse placental lactogen I secretion in vitro.

Antibody-catalyzed reversal of chemoselectivity.

Mutational analysis of the helper component-proteinase gene of a potyvirus: effects of amino acid substitutions, deletions, and gene replacement on virulence and aphid transmissibility.

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

Correlations between isochores and chromosomal bands in the human genome.

A neo-Darwinian algorithm: asymmetrical mutations due to semiconservative DNA-type replication promote evolution.

Biotinylated diaminopyridine: an approach to tagging oligosaccharides and exploring their biology.

Mathematical textbook of deformable neuroanatomies.

Immunocytochemical localization of the plasma membrane calcium pump, calbindin-D28k, and parvalbumin in Purkinje cells of avian and mammalian cerebellum.

Transcriptional regulatory elements downstream of the JunB gene.

Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease.

Aspartate transcarbamoylase containing circularly permuted catalytic polypeptide chains.

Two functionally distinct forms of the photosystem II reaction-center protein D1 in the cyanobacterium Synechococcus sp. PCC 7942.

The SRY high-mobility-group box recognizes DNA by partial intercalation in the minor groove: a topological mechanism of sequence specificity.

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

Allele-specific peptide ligand motifs of HLA-C molecules.

Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.

Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells.

Cloning and characterization of subunit genes of ribonucleotide reductase, a cell-cycle-regulated enzyme, from Plasmodium falciparum.

Deficient transcription of XIST from tiny ring X chromosomes in females with severe phenotypes.

The gene responsible for Werner syndrome may be a cell division 'counting' gene.

In vivo protection against endotoxin by plasma high density lipoprotein.

apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

Protein kinase C and F1/GAP-43 gene expression in hippocampus inversely related to synaptic enhancement lasting 3 days.

Year: 1993 Volume: 90 Issue: 23

Year: 1993 Volume: 90 Issue: 22

Year: 1993 Volume: 90 Issue: 21

Year: 1993 Volume: 90 Issue: 20

Year: 1993 Volume: 90 Issue: 19

Year: 1993 Volume: 90 Issue: 18

Year: 1993 Volume: 90 Issue: 17

Year: 1993 Volume: 90 Issue: 16

Year: 1993 Volume: 90 Issue: 15

Year: 1993 Volume: 90 Issue: 14

Year: 1993 Volume: 90 Issue: 13

Year: 1993 Volume: 90 Issue: 12

Year: 1993 Volume: 90 Issue: 11

Year: 1993 Volume: 90 Issue: 10

Year: 1993 Volume: 90 Issue: 9

Year: 1993 Volume: 90 Issue: 8

Year: 1993 Volume: 90 Issue: 7

Year: 1993 Volume: 90 Issue: 6

Year: 1993 Volume: 90 Issue: 5

Year: 1993 Volume: 90 Issue: 4

Year: 1993 Volume: 90 Issue: 3

Year: 1993 Volume: 90 Issue: 2

Year: 1993 Volume: 90 Issue: 1

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cara, J. F. Zhong, P. Tager, H. S.
Description	Author Affiliation: Zhong P ( Department of Biochemistry, University of Chicago, IL 60637.);
Abstract	We have investigated by use of placental membranes the mechanisms through which insulin-like growth factor I (IGF-I) comes to be associated with its alpha 2 beta 2 receptor heterotetramer. Our results suggest that (i) at low ligand concentrations, the formation and disruption of IGF-I--receptor complexes are consistent with ligand binding de novo to empty receptors but not with equilibria involving ligand dissociation; (ii) at higher ligand concentrations, rapid exchange arising from the formation and collapse of bis-liganded receptors leads to a transiently perturbed receptor state; (iii) these nonclassical IGF-I receptor interactions depend on close communication between the alpha beta halves of the alpha 2 beta 2 holo-IGF-I receptor; and (iv) related processes based on ligand exchange have the potential for serving as biological sensors of changes in ligand concentration, while ordinary binding processes serve as sensors of ligand concentrations themselves. A model is presented in which one or two molecules of ligand can be bound to an alpha 2 beta 2 IGF-I receptor heterotetramer, new ligand becomes associated with receptor by exchanging for a previously bound molecule of IGF-I, and fluctuating changes in free-ligand concentration might lead to enhanced IGF-I function.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Insulin-Like Growth Factor I Metabolism Placenta Receptor, IGF Type 1 Cell Membrane Iodine Radioisotopes Kinetics Macromolecular Substances Models, Theoretical Pregnancy Protein Binding Radioligand Assay Isolation & Purification Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in