NDLI: apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

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apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

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apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, C. Daigle, I.
Description	Author Affiliation: Daigle I ( Department of Biology, Boston University, MA 02215.);
Abstract	The major component of senile plaques found in the brains of Alzheimer disease patients is the beta-amyloid peptide, which is derived from a larger amyloid precursor protein (APP). Recently, a number of APP and APP-related proteins have been identified in different organisms and constitute the family of APP proteins. We have isolated several cDNAs encoding an APP-related protein in the nematode Caenorhabditis elegans and have designated the corresponding gene as apl-1. The apl-1 transcripts undergo two forms of posttranscriptional modification: trans-splicing and alternative polyadenylylation. In vitro translation of an apl-1 cDNA results in a protein of approximately the expected size. Similar to the Drosophila, human, and mouse APP-related proteins, APL-1 does not appear to contain the beta-amyloid peptide. Because APP-related proteins seem to be conserved through evolution, the apl-1 gene from C. elegans should be important for determining the normal function of human APP.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amyloid Beta-Protein Precursor Genetics Caenorhabditis Elegans Proteins Caenorhabditis Elegans Metabolism Helminth Proteins Membrane Proteins Alternative Splicing Amino Acid Sequence Animals Growth & Development DNA Primers Biosynthesis Molecular Sequence Data Oligodeoxyribonucleotides Polymerase Chain Reaction Protein Biosynthesis Protein Sorting Signals Sequence Homology, Amino Acid Transcription, Genetic Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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