NDLI: Sequence analysis of the core gene of 14 hepatitis C virus genotypes.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1994 Volume: 91 Issue: 26

Year: 1994 Volume: 91 Issue: 26 Suppl

Year: 1994 Volume: 91 Issue: 25

Year: 1994 Volume: 91 Issue: 24

Year: 1994 Volume: 91 Issue: 23

Year: 1994 Volume: 91 Issue: 22

Year: 1994 Volume: 91 Issue: 21

Year: 1994 Volume: 91 Issue: 20

Year: 1994 Volume: 91 Issue: 19

Year: 1994 Volume: 91 Issue: 18

Year: 1994 Volume: 91 Issue: 17

Host fidelity is an effective premating barrier between sympatric races of the apple maggot fly.

Agrobacterium tumefaciens transfers single-stranded transferred DNA (T-DNA) into the plant cell nucleus.

Contrasting the distribution of chloroplast DNA and allozyme polymorphism among local populations of Silene alba: implications for studies of gene flow in plants.

Dephosphorylation of sperm midpiece antigens initiates aster formation in rabbit oocytes.

Mode of action of anti-lipopolysaccharide-binding protein antibodies for prevention of endotoxemic shock in mice.

Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.

Impulse flow dependency of galanin release in vivo in the rat ventral hippocampus.

A purified selenophosphate-dependent enzyme from Salmonella typhimurium catalyzes the replacement of sulfur in 2-thiouridine residues in tRNAs with selenium.

Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease.

The expression of serine carboxypeptidases during maturation and germination of the barley grain.

Dopamine alters glutamate receptor desensitization in retinal horizontal cells of the perch (Perca fluviatilis).

Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice.

Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1.

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.

Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines.

Apoptosis in substantia nigra following developmental striatal excitotoxic injury.

Visualizing hippocampal synaptic function by optical detection of Ca2+ entry through the N-methyl-D-aspartate channel.

Differential expression of autoreceptors in the ascending dopamine systems of the human brain.

Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.

Songbirds and adult neurogenesis: a new role for hormones.

Cell death and neuronal recruitment in the high vocal center of adult male canaries are temporally related to changes in song.

The life span of new neurons in a song control nucleus of the adult canary brain depends on time of year when these cells are born.

Testosterone increases the recruitment and/or survival of new high vocal center neurons in adult female canaries.

Antisense phosphorothioate oligonucleotides: selective killing of the intracellular parasite Leishmania amazonensis.

Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.

Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.

Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.

Calpain (Ca(2+)-dependent thiol protease) in erythrocytes of young and old individuals.

Independent in vitro assembly of a ribonucleoprotein particle containing the 3' domain of 16S rRNA.

Immunotherapy with anti-CD3 monoclonal antibodies and recombinant interleukin 2: stimulation of molecular programs of cytotoxic killer cells and induction of tumor regression.

The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.

Iron reverses impermeable chelator inhibition of DNA synthesis in CCl 39 cells.

Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo.

Phylogeny and evolution of the auks (subfamily Alcinae) based on mitochondrial DNA sequences.

Epistatic interaction and functional compensation between the two tissue- and cell-specific sucrose synthase genes in maize.

Phosphorylation enhances the target gene sequence-dependent dimerization of thyroid hormone receptor with retinoid X receptor.

Strand displacement amplification as an in vitro model for rolling-circle replication: deletion formation and evolution during serial transfer.

Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells.

A point mutation in Euglena gracilis chloroplast tRNA(Glu) uncouples protein and chlorophyll biosynthesis.

Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells.

Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition.

Matrix decompositions of two-dimensional nuclear magnetic resonance spectra.

The genome of the THE I human transposable repetitive elements is composed of a basic motif homologous to an ancestral immunoglobulin gene sequence.

Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag-Pol polyprotein.

Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells.

Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling.

A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis.

Evidence for aberrant auditory anatomy in developmental dyslexia.

A parathyroid hormone antagonist stimulates epidermal proliferation and hair growth in mice.

gp160, a tissue-specific marker for insulin-activated glucose transport.

Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.

A single 43-bp sopC repeat of plasmid mini-F is sufficient to allow assembly of a functional nucleoprotein partition complex.

Quantitation of human immunodeficiency virus type 1 during pregnancy: relationship of viral titer to mother-to-child transmission and stability of viral load.

Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.

SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

The active site of RNA polymerase II participates in transcript cleavage within arrested ternary complexes.

Intra-host versus inter-host selection: viral strategies of immune function impairment.

Molecular characterization of J558 genes encoding tight-skin mouse autoantibodies: identical heavy-chain variable genes code for antibodies with different specificities.

Inhibition of proopiomelanocortin expression by an oligodeoxynucleotide complementary to beta-endorphin mRNA.

Regulation of ROMK1 K+ channel activity involves phosphorylation processes.

The ctpA gene encodes the C-terminal processing protease for the D1 protein of the photosystem II reaction center complex.

Cleavage of the nascent transcript induced by TFIIS is insufficient to promote read-through of intrinsic blocks to elongation by RNA polymerase II.

Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology.

Linkage of a human brain malformation, familial holoprosencephaly, to chromosome 7 and evidence for genetic heterogeneity.

Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia.

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes.

A functional anatomical study of associative learning in humans.

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 91 Issue: 17)

DNA double helix promotes a linkage isomerization reaction in trans-diamminedichloroplatinum(II)-modified DNA.

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

Intrinsic 5-lipoxygenase activity is required for neutrophil responsivity.

Chromosomal speciation and adaptive radiation of mole rats in Asia Minor correlated with increased ecological stress.

Nonpeptide ligands for human gamma delta T cells.

A regulatory system for use in gene transfer.

Gene therapy of rat 9L gliosarcoma tumors by transduction with selectable genes does not require drug selection.

Hypothesis: disseminated intravascular inflammation as the inflammatory counterpart to disseminated intravascular coagulation.

A third synaptotagmin gene, Syt3, in the mouse.

Alcohol action on a neuronal membrane receptor: evidence for a direct interaction with the receptor protein.

Electrophysiological analysis of Na+/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes.

Feedback regulation of cell-substratum adhesion by integrin-mediated intracellular Ca2+ signaling.

Universal signals control slime mold stalk formation.

Electron microscopic studies of the interaction between a Bacillus subtilis alpha/beta-type small, acid-soluble spore protein with DNA: protein binding is cooperative, stiffens the DNA, and induces negative supercoiling.

The conserved core domain of the human TATA binding protein is sufficient to assemble the multisubunit RNA polymerase I-specific transcription factor SL1.

Structural order of membranes and composition of phospholipids in fish brain cells during thermal acclimatization.

Sequence analysis of the core gene of 14 hepatitis C virus genotypes.

Cold denaturation of a repressor-operator complex: the role of entropy in protein-DNA recognition.

NMR structure of a biologically active peptide containing the RNA-binding domain of human immunodeficiency virus type 1 Tat.

N,N'-dicyclohexylcarbodiimide cross-linking suggests a central core of helices II in oligomers of URF13, the pore-forming T-toxin receptor of cms-T maize mitochondria.

An essential gene of Saccharomyces cerevisiae coding for an actin-related protein.

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

The relationship between genetic and physical distances in the cloned a1-sh2 interval of the Zea mays L. genome.

Lambda foo: a lambda phage vector for the expression of foreign proteins.

Characterization of glucose transport and cloning of a hexose transporter gene in Trypanosoma cruzi.

Differential expression of mRNAs for JC virus large and small tumor antigens in brain tissues from progressive multifocal leukoencephalopathy patients with and without AIDS.

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.

Year: 1994 Volume: 91 Issue: 16

Year: 1994 Volume: 91 Issue: 15

Year: 1994 Volume: 91 Issue: 14

Year: 1994 Volume: 91 Issue: 13

Year: 1994 Volume: 91 Issue: 12

Year: 1994 Volume: 91 Issue: 11

Year: 1994 Volume: 91 Issue: 10

Year: 1994 Volume: 91 Issue: 9

Year: 1994 Volume: 91 Issue: 8

Year: 1994 Volume: 91 Issue: 7

Year: 1994 Volume: 91 Issue: 6

Year: 1994 Volume: 91 Issue: 5

Year: 1994 Volume: 91 Issue: 4

Year: 1994 Volume: 91 Issue: 3

Year: 1994 Volume: 91 Issue: 2

Year: 1994 Volume: 91 Issue: 1

Impact melting of frozen oceans on the early Earth: Implications for the origin of life

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Sequence analysis of the core gene of 14 hepatitis C virus genotypes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Purcell, R. H. Miller, R. H. Bukh, J.
Description	Author Affiliation: Bukh J ( Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.);
Abstract	We previously sequenced the 5' noncoding region of 44 isolates of hepatitis C virus (HCV), as well as the envelope 1 (E1) gene of 51 HCV isolates, and provided evidence for the existence of at least 6 major genetic groups consisting of at least 12 minor genotypes of HCV (i.e., genotypes I/1a, II/1b, III/2a, IV/2b, 2c, V/3a, 4a-4d, 5a, and 6a). We now report the complete nucleotide sequence of the putative core (C) gene of 52 HCV isolates that represent all of these 12 genotypes as well as two additional genotypes provisionally designated 4e and 4f that we identified in this study. The phylogenetic analysis of the C gene sequences was in agreement with that of the E1 gene sequences. A major division in the genetic distance was observed between HCV isolates of genotype 2 and those of the other genotypes in analysis of both the E1 and C genes. The C gene sequences of 9 genotypes have not been reported previously (i.e., genotypes 2c, 4a-4f, 5a, and 6a). Our analysis indicates that the C gene-based methods currently used to determine the HCV genotype, such as PCR with genotype-specific primers, should be revised in light of these data. We found that the predicted C gene was exactly 573 nt long in all 52 HCV isolates, with an N-terminal start codon and no in-frame stop codons. The nucleotide and predicted amino acid identities of the C gene sequences were in the range of 79.4-99.0% and 85.3-100%, respectively. Furthermore, we mapped universally conserved, as well as genotype-specific, nucleotide and deduced amino acid sequences of the C gene. The predicted C proteins of the different HCV genotypes shared the following features: (i) high content of proline residues, (ii) high content of arginine and lysine residues located primarily in three domains with 10 such residues invariant at positions 39-62, (iii) a cluster of 5 conserved tryptophan residues, (iv) two nuclear localization signals and a DNA-binding motif, (v) a potential phosphorylation site with a serine-proline motif, and (vi) three conserved hydrophilic domains that have been shown by others to contain immunogenic epitopes. Thus, we have extended analysis of the predicted C protein of HCV to all of the recognized genotypes, confirmed the existence of highly conserved regions of this important structural protein, and demonstrated that the genetic relatedness of HCV isolates is equivalent when analyzing the most conserved (i.e., C) and the most variable (i.e., E1) genes of the HCV genome.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Viral Hepacivirus Genetics Phylogeny Viral Core Proteins Amino Acid Sequence Consensus Sequence Genotype Isolation & Purification Hepatitis C Blood Microbiology Molecular Sequence Data Polymerase Chain Reaction Sequence Homology, Amino Acid Comparative Study Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in