NDLI: Genetic organization and diversity of the hepatitis C virus.

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Biosynthesis of the thiazole moiety of thiamin (vitamin B1) in higher plant chloroplasts.

Diacylglycerols induce both ion pumping in patch-clamped guard-cell protoplasts and opening of intact stomata.

Einstein's equations with an embedding-dependent energy-momentum tensor for the compactified Minkowski time space and their relationship to the conformal action of SO(4,4) on S3 x S3.

Differential scanning calorimetry of plant cell walls.

Identification and characterization of nonsedimentable lipid-protein microvesicles.

Approximate entropy as a measure of system complexity.

Bergmann's rule near the equator: latitudinal clines in body size of an Andean passerine bird.

The second amino acid of alfalfa mosaic virus coat protein is critical for coat protein-mediated protection.

Assimilate movement dictates remote sites of wound-induced gene expression in poplar leaves.

Gene I, a potential cell-to-cell movement locus of cauliflower mosaic virus, encodes an RNA-binding protein.

Interspecific gene flow in sympatric oaks.

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

Regulation of luteinizing hormone-releasing hormone receptor binding by heterologous and autologous receptor-stimulated tyrosine phosphorylation.

Quox-1, a quail homeobox gene expressed in the embryonic central nervous system, including the forebrain.

Distinct muscarinic receptors inhibit release of gamma-aminobutyric acid and excitatory amino acids in mammalian brain.

Design, synthesis, and functional expression of a gene for charybdotoxin, a peptide blocker of K+ channels.

Dendritic location of neural BC1 RNA.

Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles.

Isolation and characterization of a cDNA clone encoding an alternative oxidase protein of Sauromatum guttatum (Schott).

Straight and paired helical filaments in Alzheimer disease have a common structural unit.

Ultrasensitive fluorometric detection of carbohydrates as derivatives in mixtures separated by capillary electrophoresis.

Transcript elongation and termination are competitive kinetic processes.

Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase.

Adhesion protein GMP140 inhibits superoxide anion release by human neutrophils.

Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.

Regional differences in calcium-release channels from heart.

The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins.

Primary structure of the precursor for the sea anemone neuropeptide Antho-RFamide (less than Glu-Gly-Arg-Phe-NH2).

Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy.

Receptor-stimulated death pathway is opened by antigen in mature T cells.

The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.

Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning.

TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants.

Proton transfer is rate-limiting for translocation of precursor proteins by the Escherichia coli translocase.

RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.

Primary structure and ontogeny of an avian CD3 transcript.

Immunological suppression by human CD8+ T cells is receptor dependent and HLA-DQ restricted.

FVB/N: an inbred mouse strain preferable for transgenic analyses.

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo.

Reconstitution of high-affinity opioid agonist binding in brain membranes.

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Inositol trisphosphate receptor: phosphorylation by protein kinase C and calcium calmodulin-dependent protein kinases in reconstituted lipid vesicles.

Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.

Shaping and reshaping of salmonid genomes by amplification of tRNA-derived retroposons during evolution.

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Expression of the human apolipoprotein E gene suppresses steroidogenesis in mouse Y1 adrenal cells.

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A constitutively active holoenzyme form of the cAMP-dependent protein kinase.

Genetic organization and diversity of the hepatitis C virus.

Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation.

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Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes.

Erythropoietin receptors induced by dimethyl sulfoxide exhibit positive cooperativity associated with an amplified biologic response.

Nature and functional implications of the cytochrome a3 transients after photodissociation of CO-cytochrome oxidase.

Evidence for thymopoietin and thymopoietin/alpha-bungarotoxin/nicotinic receptors within the brain.

A second maternally expressed Drosophila gene encodes a putative RNA helicase of the 'DEAD box' family.

Laventiana annectens, new genus and species: fossil evidence for the origins of callitrichine New World monkeys.

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

The transcriptional regulator LevR of Bacillus subtilis has domains homologous to both sigma 54- and phosphotransferase system-dependent regulators.

The pituitary gland is required for protection against lethal effects of Salmonella typhimurium.

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

Norepinephrine and isoproterenol increase the phosphorylation of synapsin I and synapsin II in dentate slices of young but not aged Fisher 344 rats.

Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells.

Locations of the three primary binding sites for long-chain fatty acids on bovine serum albumin.

Incorporation of 12-methoxydodecanoate into the human immunodeficiency virus 1 gag polyprotein precursor inhibits its proteolytic processing and virus production in a chronically infected human lymphoid cell line.

Molecular evolution of alcohol dehydrogenase 1 in members of the grass family.

Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.

Unexpected, spontaneous conversion of a family of rats, from low-leukemic to high-leukemic inbred line.

Cocaine-induced reduction of brain neuropeptide Y synthesis dependent on medial prefrontal cortex.

A novel cytoarchitectonic area induced experimentally within the primate visual cortex.

Corticosterone levels determine individual vulnerability to amphetamine self-administration.

Determination of pathways of glycogen synthesis and the dilution of the three-carbon pool with [U-13C]glucose.

Stable integrative transformation of Trypanosoma brucei that occurs exclusively by homologous recombination.

Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene.

Founder effect of a prevalent phenylketonuria mutation in the Oriental population.

Different mRNAs code for dopa decarboxylase in tissues of neuronal and nonneuronal origin.

Stable integration and expression in mouse cells of yeast artificial chromosomes harboring human genes.

Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120.

Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities.

Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I.

Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain.

X-ray diffraction study of the binding of the antisickling agent 12C79 to human hemoglobin.

Transforming function of proto-ras genes depends on heterologous promoters and is enhanced by specific point mutations.

Dual site model for the organogenic activity of angiogenin.

An angiogenin-binding protein from endothelial cells.

Identification and purification to near homogeneity of the vitamin K-dependent carboxylase.

A soluble factor induced by an extract from Pinus parviflora Sieb et Zucc can inhibit the replication of human immunodeficiency virus in vitro.

Transport of lipoprotein lipase across endothelial cells.

Transcription is associated with Z-DNA formation in metabolically active permeabilized mammalian cell nuclei.

An enhancer variant of Moloney murine leukemia virus defective in leukemogenesis does not generate detectable mink cell focus-inducing virus in vivo.

Mechanisms associated with the generation of biologically active human immunodeficiency virus type 1 particles from defective proviruses.

A pioneering growth cone in the embryonic zebrafish brain.

Curved DNA without A-A: experimental estimation of all 16 DNA wedge angles.

Methylation patterns of testis-specific genes.

Rapid identification of markers linked to a Pseudomonas resistance gene in tomato by using random primers and near-isogenic lines.

Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: an in vitro study relevant to bone marrow purging.

Odorant-sensitive adenylate cyclase: rapid, potent activation and desensitization in primary olfactory neuronal cultures.

Splice junctions follow a 205-base ladder.

Protein dynamics in the bacteriorhodopsin photocycle: submillisecond Fourier transform infrared spectra of the L, M, and N photointermediates.

Error bounds for the fundamental and secondary theorems of natural selection.

Protamine transcript sharing among postmeiotic spermatids.

Identity of a second type of allatostatin from cockroach brains: an octadecapeptide amide with a tyrosine-rich address sequence.

DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies.

Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex.

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A self-assembling protein kinase C inhibitor.

High level expression in Escherichia coli of soluble, enzymatically active schistosomal hypoxanthine/guanine phosphoribosyltransferase and trypanosomal ornithine decarboxylase.

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Characterization of a nuclear protein that binds to three elements within the silencer region of a bean chalcone synthase gene promoter.

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Receptors of the serotonin 1C subtype expressed from cloned DNA mediate the closing of K+ membrane channels encoded by brain mRNA.

Chemiluminescence detection of proteins from single cells.

Regulation of rhodopsin kinase by autophosphorylation.

Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice.

Primary structures of the precursor and mature forms of stearoyl-acyl carrier protein desaturase from safflower embryos and requirement of ferredoxin for enzyme activity.

The reaction of hydroxylamine with bacteriorhodopsin studied with mutants that have altered photocycles: selective reactivity of different photointermediates.

CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.

Evolution of parasitism: kinetoplastid protozoan history reconstructed from mitochondrial rRNA gene sequences. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 88 Issue: 6)

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Two-dimensional life?

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Genetic organization and diversity of the hepatitis C virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Medina-selby, R. Barr, P. J. Coit, D. Han, J. H. Berger, K. Richman, K. H. Choo, Q. L. Dong, C. Lee, C. Gallegos, C.
Description	Author Affiliation: Choo QL ( Chiron Corporation, Emeryville, CA 94608.);
Abstract	The nucleotide sequence of the RNA genome of the human hepatitis C virus (HCV) has been determined from overlapping cDNA clones. The sequence (9379 nucleotides) has a single large open reading frame that could encode a viral polyprotein precursor of 3011 amino acids. While there as little overall amino acid and nucleotide sequence homology with other viruses, the 5' HCV nucleotide sequence upstream of this large open reading frame has substantial similarity to the 5' termini of pestiviral genomes. The polyprotein also has significant sequence similarity to helicases encoded by animal pestiviruses, plant potyviruses, and human flaviviruses, and it contains sequence motifs widely conserved among viral replicases and trypsin-like proteases. A basic, presumed nucleocapsid domain is located at the N terminus upstream of a region containing numerous potential N-linked glycosylation sites. These HCV domains are located in the same relative position as observed in the pestiviruses and flaviviruses and the hydrophobic profiles of all three viral polyproteins are similar. These combined data indicate that HCV is an unusual virus that is most related to the pestiviruses. Significant genome diversity is apparent within the putative 5' structural gene region of different HCV isolates, suggesting the presence of closely related but distinct viral genotypes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Viral Genetic Variation Hepacivirus Genetics Amino Acid Sequence Animals Isolation & Purification Molecular Sequence Data Oligonucleotide Probes Pan Troglodytes Protein Conformation RNA, Viral Sequence Homology, Nucleic Acid Viral Proteins Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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