NDLI: Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates.

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Geometric interpretation of vertex operator algebras.

Post's program and incomplete recursively enumerable sets.

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Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates.

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Two-dimensional life?

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Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, D. H. Inchauspe, G. Prince, A. M. Zebedee, S. Sugitani, M. Nasoff, M.
Spatial Coverage	United States
Description	Author Affiliation: Inchauspe G ( Lindsley F. Kimball Research Institute, New York Blood Center, Laboratory of Virology and Parasitology, NY 10021.);
Abstract	Genomic RNA from the human prototype strain H of the hepatitis C virus (HCV-H) has been molecularly cloned and sequenced. The HCV-H sequence reported consists of 9416 nucleotides including the 5' and 3' untranslated regions. HCV-H shows 96% amino acid identity with the American isolate HCV-1 but only 84.9% with the Japanese isolates HCV-J and HCV-BK. In addition to the hypervariable region (region V) previously identified in the putative E2 domain, three other variable domains were identified: region V1 (putative E1), region V2 (putative E2), and region V3 (putative NS5). These regions appear rather conserved (86-100%) among the American isolates (HCV-1 and HC-J1) or among various Japanese isolates (HCV-J, HCV-BK, HCV-JH, and HC-J4) but show striking heterogeneity when the two subgroups are compared (42-87.5% amino acid difference). A structural similarity between the 5'-terminal hairpin structure of HCV and of poliovirus was observed. This study further suggests the existence of at least two genomic subtypes of HCV and confirms a distant relationship between HCV and pestiviruses.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genome, Viral Hepacivirus Genetics Amino Acid Sequence Animals Cloning, Molecular DNA, Viral Isolation & Purification Genetic Variation Hepatitis C Microbiology Liver Molecular Sequence Data Nucleic Acid Conformation Pan Troglodytes Poliovirus Polymerase Chain Reaction RNA, Viral Sequence Homology, Nucleic Acid Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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