NDLI: Identification of the promoter of the mouse obese gene.

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Earthquake prediction: the scientific challenge.

Earthquake prediction: the interaction of public policy and science.

Initiation process of earthquakes and its implications for seismic hazard reduction strategy.

Intermediate- and long-term earthquake prediction.

Scale dependence in earthquake phenomena and its relevance to earthquake prediction.

Intermediate-term earthquake prediction.

A selective phenomenology of the seismicity of Southern California.

The repetition of large-earthquake ruptures.

Hypothesis testing and earthquake prediction.

What electrical measurements can say about changes in fault systems.

Geochemical challenge to earthquake prediction.

Implications of fault constitutive properties for earthquake prediction.

Nonuniformity of the constitutive law parameters for shear rupture and quasistatic nucleation to dynamic rupture: a physical model of earthquake generation processes.

Rock friction and its implications for earthquake prediction examined via models of Parkfield earthquakes.

Slip complexity in earthquake fault models.

Dynamic friction and the origin of the complexity of earthquake sources.

Slip complexity in dynamic models of earthquake faults.

The organization of seismicity on fault networks.

Geometric incompatibility in a fault system.

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Motor learning by field approximation.

The effects of sequence context on DNA curvature.

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Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains.

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Identification of the promoter of the mouse obese gene.

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Identification of the promoter of the mouse obese gene.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	De La Brousse, F. C. Shan, B. Chen, J. L.
Description	Author Affiliation: de la Brousse FC ( Tularik Inc., South San Francisco, CA 94080, USA.);
Abstract	Primer extension and RACE (rapid amplification of cDNA ends) assays were used to identify and sequence the 5' terminus of mouse ob mRNA. This sequence was used to obtain a recombinant bacteriophage containing the first exon of the encoding gene. DNA sequence analysis of the region immediately upstream of the first exon of the mouse ob gene revealed DNA sequences corresponding to presumptive cis-regulatory elements. A canonical TATA box was observed 30-34 base pairs upstream from the start site of transcription and a putative binding site for members of the C/EBP family of transcription factors was identified immediately upstream from the TATA box. Nuclear extracts prepared from primary adipocytes contained a DNA binding activity capable of avid and specific interaction with the putative C/EBP response element; antibodies to C/EBP alpha neutralized the DNA binding activity present in adipocyte nuclear extracts. When linked to a firefly luciferase reporter and transfected into primary adipocytes, the presumptive promoter of the mouse ob gene facilitated luciferase expression. When transfected into HepG2 cells, which lack C/EBP alpha, the mouse ob promoter was only weakly active. Supplementation of C/EBP alpha by cotransfection with a C/EBP alpha expression vector markedly stimulated luciferase expression. Finally, an ob promoter variant mutated at the C/EBP response element was inactive in both primary adipocytes and HepG2 cells. These observations provide evidence for identification of a functional promoter capable of directing expression of the mouse ob gene.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adipose Tissue Metabolism Obesity Genetics Promoter Regions, Genetic Proteins Animals Cell Nucleus Cloning, Molecular DNA Primers Exons Leptin Luciferases Biosynthesis Mice Mice, Inbred C57BL Mice, Obese Molecular Sequence Data Oligonucleotides, Antisense Polymerase Chain Reaction Protein Biosynthesis Recombinant Fusion Proteins Restriction Mapping TATA Box Transcription, Genetic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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