NDLI: Potentiation of the bioavailability of daidzin by an extract of Radix puerariae.

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Earthquake prediction: the scientific challenge.

Earthquake prediction: the interaction of public policy and science.

Initiation process of earthquakes and its implications for seismic hazard reduction strategy.

Intermediate- and long-term earthquake prediction.

Scale dependence in earthquake phenomena and its relevance to earthquake prediction.

Intermediate-term earthquake prediction.

A selective phenomenology of the seismicity of Southern California.

The repetition of large-earthquake ruptures.

Hypothesis testing and earthquake prediction.

What electrical measurements can say about changes in fault systems.

Geochemical challenge to earthquake prediction.

Implications of fault constitutive properties for earthquake prediction.

Nonuniformity of the constitutive law parameters for shear rupture and quasistatic nucleation to dynamic rupture: a physical model of earthquake generation processes.

Rock friction and its implications for earthquake prediction examined via models of Parkfield earthquakes.

Slip complexity in earthquake fault models.

Dynamic friction and the origin of the complexity of earthquake sources.

Slip complexity in dynamic models of earthquake faults.

The organization of seismicity on fault networks.

Geometric incompatibility in a fault system.

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Potentiation of the bioavailability of daidzin by an extract of Radix puerariae.

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Potentiation of the bioavailability of daidzin by an extract of Radix puerariae.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lazo, O. Vallee, B. L. Kunze, L. Keung, W. M.
Description	Author Affiliation: Keung WM ( Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, MA 02115, USA.);
Abstract	The dose effect of pure daidzin on the suppression of ethanol intake in Syrian golden hamsters was compared with that of crude daidzin contained in a methanol extract of Radix puerariae (RP). EC50 values estimated from the graded dose-response curves for pure daidzin and RP extract daidzin are 23 and 2.3 mg per hamster per day, respectively. Apparently the antidipsotropic activity of the RP extract cannot be accounted for solely by its daidzin content (22 mg/g). In addition to daidzin, six other isoflavones were identified in the RP extract and quantified--namely, puerarin (160 mg per g of extract), genistin (3.7 mg/g), daidzein (2.6 mg/g), daidzein-4',7-diglucoside (1.2 mg/g), genistein (0.2 mg/g), and formononetin (0.16 mg/g). None of these, administered either alone or combined, contributes in any significant way to the antidipsotropic activity of the extract. Plasma daidzin concentration-time curves determined in hamsters administered various doses of pure daidzin or RP extract by i.p.injection indicate that the crude extract daidzin has approximately 10 times greater bioavailability than the pure compound. Reconstruction of the dose-response effects for pure and crude daidzin using bioavailable daidzin rather than administered dose gives a single curve. Synthetic daidzin added to the RP extract acquires the bioavailability of the endogenous daidzin that exists naturally in the extract. These results show that (i) daidzin is the major active principle in methanol extracts of RP, and (ii) additional constituents in the methanol extract of RP assist uptake of daidzin in golden hamsters.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alcohol Deterrents Pharmacology Pharmacokinetics Alcohol Drinking Isoflavones Plant Extracts Plants, Medicinal Prevention & Control Animals Biological Availability Cricetinae Dose-Response Relationship, Drug Blood Mesocricetus Metabolic Clearance Rate Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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