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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Buhr, Ethan D. Lee, Choogon Chang, Suhwan Song, Eun-joo Takahashi, Joseph S. Lowrey, Phillip L. Yamazaki, Shin Yoo, Seung-hee Ko, Caroline H. Yoo, Ook Joon |
| Description | Author Affiliation: Yoo SH ( Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA.); |
| Abstract | The mouse Period2 (mPer2) locus is an essential negative-feedback element of the mammalian circadian-clock mechanism. Recent work has shown that mPer2 circadian gene expression persists in both central and peripheral tissues. Here, we analyze the mouse mPer2 promoter and identify a circadian enhancer (E2) with a noncanonical 5'-CACGTT-3' E-box located 20 bp upstream of the mPer2 transcription start site. The E2 enhancer accounts for most circadian transcriptional drive of the mPer2 locus by CLOCK:BMAL1, is a major site of DNaseI hypersensitivity in this region, and is constitutively bound by a transcriptional complex containing the CLOCK protein. Importantly, the E2 enhancer is sufficient to drive self-sustained circadian rhythms of luciferase activity in central and peripheral tissues from mPer2-E2::Luciferase transgenic mice with tissue-specific phase and period characteristics. Last, genetic analysis with mutations in Clock and Bmal1 shows that the E2 enhancer is a target of CLOCK and BMAL1 in vivo. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Circadian Rhythm Genetics E-Box Elements Enhancer Elements, Genetic Nuclear Proteins ARNTL Transcription Factors Animals Basic Helix-Loop-Helix Transcription Factors CLOCK Proteins Cell Cycle Proteins Cell Line Gene Expression Homozygote Luciferases Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Mice, Transgenic Period Circadian Proteins Promoter Regions, Genetic Protein Biosynthesis Trans-Activators Transcription Factors Transcription, Genetic Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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