NDLI: Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.

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Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.

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Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Colucci, S. Comoglio, P. M. Galimi, F. Zambonin, G. Zallone, A. Z. Cottone, E. Grano, M.
Description	Author Affiliation: Grano M ( Institute of Human Anatomy, University of Bari Medical School, Italy.);
Abstract	Hepatocyte growth factor (HGF), also known as scatter factor, is a powerful motogen, mitogen, and morphogen produced by cells of mesodermal origin, acting on epithelial and endothelial cells. Its receptor is the tyrosine kinase encoded by the c-MET protooncogene. We show that the HGF receptor is expressed by human primary osteoclasts, by osteoclast-like cell lines, and by osteoblasts. In both cell lineages, HGF stimulation triggers the receptor kinase activity and autophosphorylation. In osteoclasts, HGF receptor activation is followed by increase in intracellular Ca2+ concentration and by activation of the pp60c-Src kinase. HGF induces changes in osteoclast shape and stimulates chemotactic migration and DNA replication. Osteoblasts respond to HGF by entering the cell cycle, as indicated by stimulation of DNA synthesis. Interestingly, osteoclasts were found to synthesize and secrete biologically active HGF. These data strongly suggest the possibility of an autocrine regulation of the osteoclast by HGF and a paracrine regulation of the osteoblast by the HGF produced by the osteoclast.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hepatocyte Growth Factor Pharmacology Osteoblasts Physiology Osteoclasts Receptor Protein-Tyrosine Kinases Bone Neoplasms Calcium Metabolism Cell Communication Cell Movement Drug Effects Cells, Cultured Coculture Techniques DNA Replication Enzyme Activation Giant Cell Tumors Kinetics Cytology Proto-Oncogene Proteins C-met Proto-Oncogene Proteins Pp60(c-src) Biosynthesis Time Factors Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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